Castañeda E, Becker J B, Robinson T E
Department of Psychology, University of Michigan, Ann Arbor 48109.
Life Sci. 1988;42(24):2447-56. doi: 10.1016/0024-3205(88)90343-8.
Exposure to amphetamine (AMPH) in vivo produces an enduring enhancement ('sensitization') in AMPH-stimulated striatal DA release in vitro. Experiments were conducted to determine whether striatal DA release evoked by neuronal depolarization is altered by AMPH pretreatment in a similar manner. It was found that AMPH pretreatment produced a long-lasting (at least one week) enhancement in striatal DA release evoked by AMPH, KCl or electrical field stimulation. In contrast, the basal rate of DA efflux was not altered by pretreatment condition. A mechanism by which a single change in the intracellular distribution of DA could enhance both AMPH- and depolarization-induced DA release is proposed.
体内暴露于苯丙胺（AMPH）会在体外产生AMPH刺激的纹状体多巴胺（DA）释放的持久增强（“敏化”）。进行实验以确定神经元去极化引起的纹状体DA释放是否以类似方式被AMPH预处理改变。发现AMPH预处理使AMPH、氯化钾（KCl）或电场刺激引起的纹状体DA释放产生持久（至少一周）增强。相比之下，DA流出的基础速率不受预处理条件影响。提出了一种机制，即DA细胞内分布的单一变化可增强AMPH诱导和去极化诱导的DA释放。
