Mirzamamedov S A
Med Radiol (Mosk). 1988 May;33(5):54-8.
The vascular factor in intraosseous metastasizing of malignant tumors has been studied insufficiently. The present study consisted in intravital microangiography of random bred albino rats after intraosseous implantation of sarcoma-45. Tumor development resulted in destructive changes in the zone of implantation and then in metastasis to the proximal metaphysis of a bone. Intraosseous tumor cell transfer was noted in the venous blood stream; tumor development beyond the bone occurred in the haversian and Volkmann's canals. It has been established that local readjustment of the blood vessels and three-zonal rearrangement of the blood circulation in the zone of implantation play a major role in the mechanism of intraosseous metastasis of malignant tumors.
恶性肿瘤骨内转移中的血管因素尚未得到充分研究。本研究包括对随机繁殖的白化大鼠在骨内植入肉瘤-45后进行活体微血管造影。肿瘤发展导致植入区出现破坏性变化，随后转移至骨的近端干骺端。在静脉血流中发现了骨内肿瘤细胞转移；骨外肿瘤发展发生在哈弗斯管和Volkmann管。已经确定，植入区血管的局部重新调整和血液循环的三区重排在恶性肿瘤骨内转移机制中起主要作用。
