经颅近红外刺激和运动皮层阳极直流电刺激增强皮质脊髓兴奋性。

Corticospinal excitability enhancement with simultaneous transcranial near-infrared stimulation and anodal direct current stimulation of motor cortex.

机构信息

Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Geriatric Medical Research Center, Beijing, China; Beijing Key Laboratory of Neuromodulation, Beijing, China.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

出版信息

Clin Neurophysiol. 2021 May;132(5):1018-1024. doi: 10.1016/j.clinph.2021.01.020. Epub 2021 Feb 20.

DOI:10.1016/j.clinph.2021.01.020

PMID:33743296

Abstract

OBJECTIVES

Non-invasive brain stimulation (NIBS) is beneficial to many neurological and psychiatric disorders by modulating neuroplasticity and cortical excitability. However, recent studies evidence that single type of NIBS such as transcranial direct current stimulation (tDCS) does not have meaningful clinical therapeutic responses due to their small effect size. Transcranial near-infrared stimulation (tNIRS) is a novel form of NIBS. Both tNIRS and tDCS implement its therapeutic effects by modulating cortical excitability but with different mechanisms. We hypothesized that simultaneous tNIRS and tDCS is superior to single stimulation, leading to a greater cortical excitability.

METHODS

Sixteen healthy subjects participated in a double-blind, sham-controlled, cross-over designed study. Motor evoked potentials (MEPs) were used to measure motor cortex excitability. The changes of MEP were calculated and compared in the sham condition, tDCS stimulation condition, tNIRS condition and the simultaneous tNIRS and anodal tDCS condition.

RESULTS

tDCS alone and tNIRS alone both elicited higher MEP after stimulation, while the MEP amplitude in the simultaneous tNIRS and tDCS condition was significantly higher than either tNIRS alone or tDCS alone. The enhancement lasted up to at least 30 minutes after stimulation, indicating simultaneous 820 nm tNIRS with 2 mA anodal tDCS have a synergistic effect on cortical plasticity.

CONCLUSIONS

Simultaneous application of tNIRS with tDCS produces a stronger cortical excitability effect.

SIGNIFICANCE

The simultaneous tNIRS and tDCS is a promising technology with exciting potential as a means of treatment, neuro-enhancement, or neuro-protection.

摘要

目的

通过调节神经可塑性和皮质兴奋性，非侵入性脑刺激（NIBS）对许多神经和精神疾病有益。然而，最近的研究证据表明，由于其效果较小，单一类型的 NIBS，如经颅直流电刺激（tDCS），没有有意义的临床治疗反应。经颅近红外刺激（tNIRS）是一种新型的 NIBS。tNIRS 和 tDCS 都通过调节皮质兴奋性来实现其治疗效果，但机制不同。我们假设同时进行 tNIRS 和 tDCS 优于单一刺激，从而导致更大的皮质兴奋性。

方法

16 名健康受试者参加了一项双盲、假对照、交叉设计的研究。运动诱发电位（MEPs）用于测量运动皮质兴奋性。在假刺激条件、tDCS 刺激条件、tNIRS 条件和同时进行的 tNIRS 和阳极 tDCS 条件下计算和比较 MEP 的变化。

结果

tDCS 单独和 tNIRS 单独刺激后都能引起更高的 MEP，而同时进行的 tNIRS 和 tDCS 条件下的 MEP 振幅明显高于单独进行的 tNIRS 或 tDCS。这种增强作用至少持续 30 分钟，表明 820nm 的同时 tNIRS 与 2mA 的阳极 tDCS 对皮质可塑性具有协同作用。