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生物瓣主动脉瓣活动度降低的血液动力学计算研究。

A computational study of the hemodynamics of bioprosthetic aortic valves with reduced leaflet motion.

机构信息

Johns Hopkins University, Baltimore, MD, USA.

Georgia Institute of Technology, Atlanta, GA, USA.

出版信息

J Biomech. 2021 May 7;120:110350. doi: 10.1016/j.jbiomech.2021.110350. Epub 2021 Mar 6.

Abstract

We employ a reduced degree-of-freedom aortic valve model to investigate the flow physics associated with early-stage reduced leaflet motion in bioprosthetic aortic valves. The model is coupled with a sharp-interface immersed boundary based incompressible flow solver to efficiently simulate the fluid-structure interaction. A total of 19 cases of flow through aortic valves with varying degrees of reduced leaflet motion (RLM) are considered. The characteristics of the aortic jet and the consequent aorta wall loading patterns are analyzed. Our results show that asymmetric RLM tilts the aortic jet and leads to large reverse and recirculating flow regions downstream from leaflets with restricted mobility. The changes in flow patterns increase wall pressure and shear stress fluctuations, and result in asymmetric oscillating shear on the aorta wall. These findings have implications for auscultation based diagnosis of this condition as well as the health of the aorta.

摘要

我们采用了一种简化的主动脉瓣自由度模型来研究生物瓣主动脉瓣早期瓣叶运动受限相关的流动物理特性。该模型与基于尖锐界面的浸入边界不可压缩流求解器相结合,以有效地模拟流固相互作用。总共考虑了 19 种不同程度的瓣叶运动受限(RLM)的主动脉瓣血流情况。分析了主动脉射流的特征以及由此产生的主动脉壁受力模式。我们的研究结果表明,不对称的 RLM 会使主动脉射流倾斜,并导致在瓣叶活动受限区域下游出现较大的反向和回流区域。流动模式的变化会增加壁压和切应力的波动,并导致主动脉壁的不对称振荡剪切。这些发现对于基于听诊的这种情况的诊断以及主动脉的健康状况具有重要意义。

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