Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Infectious Diseases and Tropical Medicine, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Transpl Infect Dis. 2021 Aug;23(4):e13604. doi: 10.1111/tid.13604. Epub 2021 Mar 27.
Brucellosis is a bacterial disease caused by Brucella species. The purpose of this study was to evaluate brucellosis in all types of transplant patients.
All the cases of brucellosis in transplant patients with no time and language limitations were searched and retrieved on May 20, 2020, using the following search keywords: (Brucella OR Brucellosis) AND (Transplant OR Transplantation) through the following medical databases: Web of Sciences, Google Scholar, Scopus, PubMed, and regional databases, for example, SID. All clinical features, including the time of transmission (before, during, and after transplantation), treatment protocols and medications, and patients' outcomes were investigated.
A total of 14 cases reported in 14 studies (out of 777 studies) were retrieved. Kidney (50%), liver (28.5%), and hematopoietic stem cell transplantation (14.2%) were the most reported types of transplantation. The presentation of brucellosis in 42.8% of the patients occurred in the early post-transplantation period, whereas 57.1% of the cases presented with late onset disease.
Brucellosis in transplant recipients seems to be uncommon even in the endemic regions. However, rare cases could be transmitted through bone marrow transplantation and transfusion. Precise screening and meticulous supervision during and after transplantation might lead to a reduction in the frequency of brucellosis.
布鲁氏菌病是由布鲁氏菌属引起的细菌性疾病。本研究的目的是评估所有类型移植患者的布鲁氏菌病。
于 2020 年 5 月 20 日，通过以下医学数据库，使用以下搜索关键字，对无时间和语言限制的所有移植患者布鲁氏菌病病例进行检索：（布鲁氏菌或布鲁氏菌病）和（移植或移植）：Web of Sciences、Google Scholar、Scopus、PubMed 和区域数据库，例如 SID。调查了所有临床特征，包括传播时间（移植前、移植中和移植后）、治疗方案和药物以及患者结局。
共检索到 14 项研究中的 14 例（777 项研究中的 14 例）。肾脏（50%）、肝脏（28.5%）和造血干细胞移植（14.2%）是报道最多的移植类型。42.8%的患者在移植后早期出现布鲁氏菌病，而 57.1%的患者出现迟发性疾病。
即使在流行地区，移植受者的布鲁氏菌病似乎也不常见。然而，罕见病例可能通过骨髓移植和输血传播。在移植期间和之后进行精确的筛查和细致的监测可能会降低布鲁氏菌病的频率。
