Department of Hygiene and Public Health, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka, 573-1010, Japan.
Department of Public Health, Kindai University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.
Environ Health Prev Med. 2021 Mar 20;26(1):35. doi: 10.1186/s12199-021-00959-9.
Body mass-independent parameters might be more appropriate for assessing cardiometabolic abnormalities than weight-dependent indices in Asians who have relatively high visceral adiposity but low body fat. Dual-energy X-ray absorptiometry (DXA)-measured trunk-to-peripheral fat ratio is one such body mass-independent index. However, there are no reports on relationships between DXA-measured regional fat ratio and cardiometabolic risk factors targeting elderly Asian men.
We analyzed cross-sectional data of 597 elderly men who participated in the baseline survey of the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study, a community-based single-center prospective cohort study conducted in Japan. Whole-body fat and regional fat were measured with a DXA scanner. Trunk-to-appendicular fat ratio (TAR) was calculated as trunk fat divided by appendicular fat (sum of arm and leg fat), and trunk-to-leg fat ratio (TLR) as trunk fat divided by leg fat.
Both TAR and TLR in the group of men who used ≥ 1 medication for hypertension, dyslipidemia, or diabetes ("user group"; N = 347) were significantly larger than those who did not use such medication ("non-user group"; N = 250) (P < 0.05). After adjusting for potential confounding factors including whole-body fat, both TAR and TLR were significantly associated with low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, fasting serum insulin, and the insulin resistance index in the non-user group and non-overweight men in the non-user group (N = 199).
The trunk-to-peripheral fat ratio was associated with cardiometabolic risk factors independently of whole-body fat mass. Parameters of the fat ratio may be useful for assessing cardiometabolic risk factors, particularly in underweight to normal-weight populations.
在亚洲人群中，体脂分布多集中于内脏，体脂相对较低，而体重依赖指数可能无法准确评估此类人群的代谢异常。与体重相关的参数可能无法准确评估此类人群的代谢异常。双能 X 射线吸收法（DXA）测量的躯干部位与外周脂肪比值就是一种不依赖于体重的参数。然而，目前尚无研究报道针对老年亚洲男性，DXA 测量的躯干部位与外周脂肪比值与心血管代谢危险因素之间的关系。
我们分析了参加日本富士见町骨质疏松症风险男性（FORMEN）研究的 597 名老年男性的基线调查的横断面数据。该研究是一项以社区为基础的单中心前瞻性队列研究。使用 DXA 扫描仪测量全身脂肪和局部脂肪。躯干部位与四肢部位脂肪比值（TAR）定义为躯干部位脂肪除以四肢部位脂肪（手臂和腿部脂肪总和），躯干部位与腿部脂肪比值（TLR）定义为躯干部位脂肪除以腿部脂肪。
在使用≥1 种降压、降脂或降糖药物的男性组（n=347）中，TAR 和 TLR 均显著大于未使用这些药物的男性组（n=250）（P＜0.05）。在调整了包括全身脂肪在内的潜在混杂因素后，在未使用药物且体重正常的男性组（n=199）中，TAR 和 TLR 与低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、空腹血清胰岛素和胰岛素抵抗指数显著相关。
躯干部位与外周脂肪比值与心血管代谢危险因素独立相关，与全身脂肪量无关。脂肪比值参数可能有助于评估心血管代谢危险因素，尤其是在体重正常或消瘦的人群中。
