Han Minmin, Cao Xiaoming, Zhang Jian, Yang Xifeng, Zhang Yi, Liu Yunfeng
Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, 030000, People's Republic of China.
First Clinical Medical College, Shanxi Medical University, Taiyuan, 030000, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 May 18;17:2065-2074. doi: 10.2147/DMSO.S457243. eCollection 2024.
This study aimed to investigate the glycometabolism, fat mass, and lean mass in primary aldosteronism (PA) during disease progression.
Patients diagnosed with PA and healthy controls (HCs) were enrolled. A flash glucose monitoring system (FGMS) and dual-energy X-ray absorptiometry (DEXA) were used to measure glucose variability and glucose target rate along with fat mass and lean mass. Comparative analysis of FGMS- or DEXA-derived parameters along with correlation analyses between these parameters and PA progression were performed.
Increased glucose variability and poor glucose target rate, along with an increased proportion of truncal fat mass, and decreased proportion of appendicular lean mass, were identified in PA group compared to those in HCs. Plasma aldosterone concentration was positively correlated with glucose variability and poor glucose target rate. Plasma renin concentration was positively correlated with the proportion of truncal fat mass and lean mass, and negatively correlated with the proportion of appendicular fat mass. Aldosterone-to-renin ratio was negatively correlated with the proportion of truncal fat mass and lean mass, and positively correlated with the proportion of appendicular fat mass.
Patients with PA presented significant differences in glycometabolism, fat mass, and lean mass compared with HCs, and these alterations correlated with PA progression.
本研究旨在调查原发性醛固酮增多症（PA）疾病进展过程中的糖代谢、脂肪量和去脂体重。
纳入诊断为PA的患者和健康对照者（HCs）。使用动态血糖监测系统（FGMS）和双能X线吸收法（DEXA）测量血糖变异性和血糖达标率以及脂肪量和去脂体重。对FGMS或DEXA得出的参数进行比较分析，并对这些参数与PA进展之间进行相关性分析。
与HCs相比，PA组患者血糖变异性增加、血糖达标率差，同时躯干脂肪量比例增加，四肢去脂体重比例降低。血浆醛固酮浓度与血糖变异性和血糖达标率差呈正相关。血浆肾素浓度与躯干脂肪量和去脂体重比例呈正相关，与四肢脂肪量比例呈负相关。醛固酮与肾素比值与躯干脂肪量和去脂体重比例呈负相关，与四肢脂肪量比例呈正相关。
与HCs相比，PA患者在糖代谢、脂肪量和去脂体重方面存在显著差异，且这些改变与PA进展相关。
