TOX作为淋巴细胞恶性肿瘤免疫治疗的潜在靶点。
TOX as a potential target for immunotherapy in lymphocytic malignancies.
作者信息
Liang Chaofeng, Huang Shuxin, Zhao Yujie, Chen Shaohua, Li Yangqiu
机构信息
Key Laboratory for Regenerative Medicine of Ministry of Education; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Department of Anatomy and Molecular Embryology, Institute of Anatomy, Ruhr-University Bochum, 44801, Bochum, Germany.
出版信息
Biomark Res. 2021 Mar 20;9(1):20. doi: 10.1186/s40364-021-00275-y.
TOX (thymocyte selection-associated HMG BOX) is a member of a family of transcriptional factors that contain the highly conserved high mobility group box (HMG-box) region. Increasing studies have shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. In this review, we summarized the biological functions of TOX and its contribution as related to lymphocytic malignancies. We also discussed the potential role of TOX as an immune biomarker and target in immunotherapy for hematological malignancies.
TOX（胸腺细胞选择相关HMG盒）是一类转录因子家族的成员，该家族包含高度保守的高迁移率族盒（HMG盒）区域。越来越多的研究表明，TOX参与维持肿瘤并促进T细胞耗竭。在本综述中，我们总结了TOX的生物学功能及其与淋巴细胞恶性肿瘤相关的作用。我们还讨论了TOX作为血液系统恶性肿瘤免疫治疗中免疫生物标志物和靶点的潜在作用。
Zotero 插件