An insight into inter-relationships among tensile strength, elastic modulus and plasticity on tabletability of single components and binary mixtures.

The evolution of tablet strength is mainly influenced by deformability (bonding area) and strength of intermolecular interactions (bonding strength) from the intrinsic material properties and tableting process, respectively. Therefore, understanding of intrinsic material attributes is important for in-silico drug product designs. The present study shows that the separate effect of the above two factors can be better understood by systematic evaluation of pure APIs and their formulations. Using tensile strength, elastic modulus and yield stress as critical material attributes, a proof of concept shown in this work emphasizes that materials with greater deformability tend to possess greater tensile strength at comparable bonding strengths. In contrast, the influence of the deformability parameter is hidden when formulations are used, leading to a scenario where the effects of bonding area and bonding strength are more inseparable.