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青年饮酒者失眠治疗效果:一项随机试点试验的次要结局。

Insomnia treatment effects among young adult drinkers: Secondary outcomes of a randomized pilot trial.

机构信息

University of Missouri School of Medicine, Columbia, MO, USA.

出版信息

Alcohol Clin Exp Res. 2021 May;45(5):1136-1148. doi: 10.1111/acer.14603. Epub 2021 Apr 5.

Abstract

BACKGROUND

Cognitive behavioral therapy for insomnia (CBT-I) has moderate-to-large effects on insomnia among young adult drinkers, with preliminary data indicating that improvements in insomnia may have downstream effects on alcohol-related consequences. However, the mechanism(s) by which insomnia treatment may facilitate reductions in alcohol-related problems is unclear. Secondary outcome data from a randomized pilot trial were used to examine CBT-I effects on four proposed mediators of the insomnia/alcohol link: alcohol craving, delay discounting, negative affect, and difficulties with emotion regulation.

METHODS

Young adults (ages 18 to 30 years) with insomnia who reported 1+ binge drinking episode (4/5+ drinks for women/men) in the past month were randomized to receive CBT-I (n = 28) or to a sleep hygiene control (n = 28). Outcomes were assessed at baseline, after 5 weeks of treatment, and at 1-month posttreatment.

RESULTS

Relative to those in sleep hygiene, CBT-I participants reported greater decreases in alcohol craving (d = 0.33) at the end of treatment and greater 1-month posttreatment decreases in delay discounting of large rewards (d = 0.42). CBT-I did not have a significant effect on delay discounting of smaller rewards or momentary negative affect. There was also no significant treatment effect on difficulties with emotion regulation, although findings were confounded by a significant group difference at baseline in difficulties with emotion regulation.

CONCLUSIONS

Treatment of insomnia may lead to improvements in alcohol craving and delay discounting of large rewards among young adult drinkers with insomnia. Additional research examining whether improvement in insomnia is a mechanism for improvement in addiction domains is warranted.

摘要

背景

认知行为疗法治疗失眠(CBT-I)对年轻成年饮酒者的失眠有中等至较大的影响,初步数据表明,失眠的改善可能对与酒精相关的后果产生下游影响。然而,失眠治疗如何促进减少与酒精相关问题的机制尚不清楚。一项随机试点试验的次要结果数据用于检验 CBT-I 对失眠/酒精关系的四个潜在中介因素的影响:酒精渴求、延迟折扣、负性情绪和情绪调节困难。

方法

有失眠症且过去一个月报告有 1 次以上 binge drinking 发作(女性/男性 4/5 次以上饮酒)的年轻成年人(18 至 30 岁)被随机分配接受 CBT-I(n = 28)或睡眠卫生对照(n = 28)。在基线、5 周治疗后和 1 个月治疗后评估结果。

结果

与睡眠卫生组相比,CBT-I 组在治疗结束时报告的酒精渴求减少更多(d = 0.33),1 个月后延迟折扣较大奖励的减少更大(d = 0.42)。CBT-I 对较小奖励的延迟折扣或瞬时负性情绪没有显著影响。尽管在情绪调节困难方面存在显著的组间差异,但治疗对情绪调节困难也没有显著的治疗效果。

结论

治疗失眠可能会改善有失眠的年轻成年饮酒者的酒精渴求和延迟折扣较大奖励。需要进一步研究,以检验改善失眠是否是改善成瘾领域的一种机制。

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