Institute of Anatomy, University of Zurich, Zurich, Switzerland; Department of Nephrology, University Hospital Zurich, Zurich, Switzerland.
Institute of Anatomy, University of Zurich, Zurich, Switzerland.
Kidney Int. 2021 Apr;99(4):803-805. doi: 10.1016/j.kint.2020.12.031.
The proximal tubule is divided anatomically into 3 distinct segments-S1 to S3-on the basis of differences in cellular ultrastructure, but the functional processes that define and shape these remain elusive. In a new study, Christensen used 3-dimensional nephron reconstruction, electron microscopy, and antibody staining to precisely map protein uptake to the structure of the proximal tubule. They reported striking axial patterns in endocytosis along the segments, which showed substantial plasticity in disease states.
近端小管在解剖学上可分为 S1 到 S3 三个不同的节段，这基于其细胞超微结构的差异，但定义和塑造这些结构的功能过程仍不明确。在一项新的研究中，Christensen 利用 3 维肾单位重建、电子显微镜和抗体染色，精确地将蛋白摄取定位到近端小管的结构上。他们报告了沿这些节段的胞吞作用的显著轴向模式，这在疾病状态下表现出相当大的可塑性。
