部分水解瓜尔胶对预防流感感染的效果。

The effect of partially hydrolyzed guar gum on preventing influenza infection.

机构信息

Department of Nutrition, Hokusei Hospital, 5-1-1 Seiryu, Chitose City, Hokkaido, 066-0081, Japan.

Department of Internal Medicine, Hokusei Hospital, 5-1-1 Seiryu, Chitose City, Hokkaido, 066-0081, Japan.

出版信息

Clin Nutr ESPEN. 2021 Apr;42:148-152. doi: 10.1016/j.clnesp.2020.11.030. Epub 2021 Feb 11.

DOI:10.1016/j.clnesp.2020.11.030

PMID:33745569

Abstract

BACKGROUND & AIMS: Seasonal influenza infection in hospitals is a serious problem, and infection prevention is important. We examined retrospectively the effect of prebiotics using partially hydrolyzed guar gum (PHGG) in the prevention of influenza infection.

METHODS

Among the patients who were admitted to Hokusei Hospital between April 2017 and March 2019, 522 patients consuming food orally (492 in the convalescent rehabilitation ward and 30 in the long-term care ward) were included in this single-center retrospective cohort study. Patients were divided into two groups: a group continuously taking PHGG (PHGG group; 172 patients in the convalescent rehabilitation ward and 16 patients in the long-term care ward) and a group not taking PHGG (non-PHGG group; 320 patients in the convalescent rehabilitation ward and 14 patients in the long-term care ward). The incidence of influenza during hospitalization, stool pH, and Bristol Stool Form Scale (BSS) at 2 months after admission (2 months after the start of PHGG intake in the PHGG group) were compared between the two groups. In addition, stool pH and BSS were compared between patients who developed influenza and those who did not.

RESULTS

A total of 24 patients developed influenza. These patients were from the non-PHGG group (12 in the convalescent rehabilitation ward and 12 in the long-term care ward), with a significant difference in the incidence of influenza between these two sub-groups (p < 0.001). The non-PHGG group had more patients with high stool pH (90th percentile or higher) (p = 0.097, not clinically significant, in the convalescent rehabilitation ward and p < 0.001 in the long-term care ward). This group also had more patients with very poor BSS (score 1 or 7) (p = 0.045 in the convalescent rehabilitation ward and p < 0.001 in the long-term care ward). In addition, patients with influenza onset had high stool pH and very poor BSS regardless of their wards.

CONCLUSION

The incidence of influenza was found to be different between patients with and without taking PHGG. Stool pH and BSS were different between patients with and without PHGG intake and those with and without influenza onset, suggesting that PHGG can affect the intestinal environment and thus contribute to reducing the incidence of influenza.

摘要

背景与目的

医院季节性流感感染是一个严重的问题，感染预防至关重要。我们回顾性研究了部分水解瓜尔胶（PHGG）益生菌对预防流感感染的效果。

方法

2017 年 4 月至 2019 年 3 月期间，在北星会医院住院的患者中，纳入 522 例经口进食的患者（康復疗养病房 492 例，长期护理病房 30 例）进行这项单中心回顾性队列研究。患者分为两组：持续服用 PHGG 组（PHGG 组；康復疗养病房 172 例，长期护理病房 16 例）和未服用 PHGG 组（非 PHGG 组；康復疗养病房 320 例，长期护理病房 14 例）。比较两组患者住院期间流感发病率、粪便 pH 值和入院后 2 个月（PHGG 组开始服用 PHGG 后 2 个月）Bristol 粪便形状量表（BSS）。此外，还比较了发生流感和未发生流感患者的粪便 pH 值和 BSS。

结果

共有 24 例患者发生流感。这些患者来自非 PHGG 组（康復疗养病房 12 例，长期护理病房 12 例），两组亚组流感发病率存在显著差异（p < 0.001）。非 PHGG 组粪便 pH 值较高（90 百分位或更高）的患者较多（p = 0.097，在康復疗养病房无临床意义，在长期护理病房 p < 0.001）。该组 BSS 非常差（评分 1 或 7）的患者也较多（p = 0.045，在康復疗养病房，p < 0.001，在长期护理病房）。此外，无论病房如何，流感发作患者的粪便 pH 值和 BSS 均较差。