Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Psychiatry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Clin Nutr ESPEN. 2021 Apr;42:381-386. doi: 10.1016/j.clnesp.2020.12.022. Epub 2021 Jan 26.
Recent researches suggest that there is a relationship between the pathogenesis of depression and serum Brain Derived Neurotrophic Factor (BDNF) levels. Therefore, the purpose of this clinical trial was to determine effect of magnesium supplementation on serum Level of BDNF, magnesium and depression status in patients with depression.
A double blind randomized clinical trial was conducted on 46 depressed subjects. The participants were randomly allocated into the magnesium (MG) and the placebo (PG) group and received 500 mg magnesium and placebo daily for 8 weeks. Beck's test was conducted and blood samples were taken at baseline and after the intervention period for analysis of serum magnesium and BDNF.
No significant differences were observed in assessed variables between the two groups at the baseline. At the end of intervention, supplementation with magnesium oxide had a significant effect on Beck's test (P = 0.01) and serum magnesium (P = 0.001), but had no significant effect on BDNF levels (P = 0.507) between the two groups.
Daily intake of 500 mg magnesium oxide for at least 8 weeks improved Beck's test score and serum magnesium in depressed patients, but had no significant effect on BDNF levels between the two groups, Which Further research is recommended.
最近的研究表明，抑郁症的发病机制与血清脑源性神经营养因子（BDNF）水平之间存在关系。因此，本临床试验的目的是确定镁补充对抑郁症患者血清 BDNF 水平、镁和抑郁状态的影响。
对 46 名抑郁症患者进行了一项双盲随机临床试验。参与者被随机分配到镁（MG）和安慰剂（PG）组，每天分别接受 500mg 镁和安慰剂，持续 8 周。在基线和干预期后进行贝克测试，并采集血样分析血清镁和 BDNF。
两组在基线时评估的变量无显著差异。干预结束时，氧化镁补充对贝克测试（P=0.01）和血清镁（P=0.001）有显著影响，但对两组的 BDNF 水平无显著影响（P=0.507）。
每日摄入 500mg 氧化镁至少 8 周可改善抑郁症患者的贝克测试评分和血清镁水平，但对两组的 BDNF 水平无显著影响，建议进一步研究。
