Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Trials. 2020 Feb 26;21(1):225. doi: 10.1186/s13063-020-4122-9.
Emerging evidence has shown that vitamin D and magnesium have anti-inflammatory and anti-depressant effects. Dietary intake of magnesium is associated with reduced body mass index, waist circumference, body fat percentage, as well as inflammatory biomarkers and depressive symptoms. Vitamin D deficiency has been linked to inflammation, obesity, and depressive symptoms. This study will test the effects of vitamin D and magnesium co-supplementation on mood, serum level of brain-derived neurotrophic factor (BDNF), inflammation, and sirtuin 1 (SIRT1) in obese women.
We will conduct an 8-week, double-blind, randomized, placebo-controlled clinical trial, in a factorial design, to evaluate the individual effects of vitamin D and magnesium, and co-supplementation of them, on mood, serum level of BDNF, inflammation, and SIRT1 in 108 obese women.
We hypothesize that vitamin D and magnesium co-supplementation may provide a new adjuvant therapy through modulation of BDNF, inflammation, and SIRT1 in obese women.
Iranian Registry of Clinical Trials, IRCT20090822002365N23. Registered on 16 August 2019.
新出现的证据表明，维生素 D 和镁具有抗炎和抗抑郁作用。镁的饮食摄入量与较低的体重指数、腰围、体脂百分比以及炎症生物标志物和抑郁症状有关。维生素 D 缺乏与炎症、肥胖和抑郁症状有关。本研究将测试维生素 D 和镁联合补充对肥胖女性情绪、血清脑源性神经营养因子（BDNF）水平、炎症和 SIRT1 的影响。
我们将进行一项为期 8 周的、双盲、随机、安慰剂对照的临床试验，采用析因设计，评估维生素 D 和镁单独以及联合补充对 108 名肥胖女性情绪、血清 BDNF 水平、炎症和 SIRT1 的影响。
我们假设维生素 D 和镁联合补充可能通过调节 BDNF、炎症和 SIRT1 为肥胖女性提供一种新的辅助治疗方法。
伊朗临床试验注册中心，IRCT20090822002365N23。注册于 2019 年 8 月 16 日。
