甲状旁腺在甲状腺和甲状旁腺手术中的识别：一种评估新型低成本基于自发荧光设备的初步研究。
Parathyroid identification during thyroid and parathyroid operations: A pilot study evaluating a novel low cost autofluorescence based device.
机构信息
Department of Surgery, St. Paul's Hospital & University of British Columbia, Vancouver, British Columbia, Canada.
Department of Electrical and Computer Engineering, Faculty of Applied Science, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Am J Surg. 2021 Jun;221(6):1150-1158. doi: 10.1016/j.amjsurg.2021.03.005. Epub 2021 Mar 13.
BACKGROUND
The aim of this study was to develop a low-cost prototype near-infrared fluorescence device that enables contrast-free, real time, high-resolution intraoperative visualization of normal and pathological parathyroid glands (PGs) by imaging their autofluorescence (AF).
METHODS
A novel near-infrared parathyroid AF (NIR-PAF) imaging device with visible laser PG targeting was developed. The device was evaluated during parathyroid and thyroid operations in a pilot clinical study.
RESULTS
Overall, of the 6 parathyroidectomies carried out in the study population a parathyroid adenoma was found to exhibit AF ex vivo in 6/6 (100%) of cases, and in vivo in 3/3 (100%) of these cases. Two of 4 thyroidectomies were evaluated in vivo and all PGs (6 PGs total) were identified by the NIR-PAF device. The NIRPAF device cost less than $1200 Canadian to build.
CONCLUSION
The inexpensive NIR-PAF device that we developed can successfully intraoperatively identify both normal and pathological PGs.
背景
本研究旨在开发一种低成本的近红外荧光设备，通过对其自发荧光（AF）成像，实现正常和病理甲状旁腺（PG）的无对比、实时、高分辨率术中可视化。
方法
开发了一种具有可见激光 PG 靶向的新型近红外甲状旁腺 AF（NIR-PAF）成像设备。该设备在甲状旁腺和甲状腺手术的试点临床研究中进行了评估。
结果
在研究人群中进行的 6 例甲状旁腺切除术，共发现甲状旁腺腺瘤在体外观测到 AF 为 6/6（100%），在体内部位为 3/3（100%）。4 例甲状腺切除术中有 2 例进行了在体评估，所有 PG（共 6 个 PG）均被 NIR-PAF 设备识别。NIR-PAF 设备的建造成本低于 1200 加元。
结论
我们开发的这种廉价的近红外荧光设备可以成功地在术中识别正常和病理 PG。
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