HLA-G 免疫检查点分子在妊娠中的作用。
Role of the HLA-G immune checkpoint molecule in pregnancy.
机构信息
CEA, DRF-Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, France; U976 HIPI Unit, IRSL, Université Paris, Paris, France.
CEA, DRF-Institut de Biologie François Jacob, Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Paris, France; U976 HIPI Unit, IRSL, Université Paris, Paris, France.
出版信息
Hum Immunol. 2021 May;82(5):353-361. doi: 10.1016/j.humimm.2021.01.003. Epub 2021 Mar 19.
The non-classical HLA class I molecule HLA-G is expressed in trophoblasts where it contributes to maternal-fetal tolerance. HLA-G has been implicated in the control of trophoblast invasion, uterine vascular remodeling, and maintenance of a local immunosuppressive state. Understanding HLA-G biology at the maternal-fetal interface is therefore a critical issue in reproduction. In this regard, we review here: (i) the effects of HLA-G on decidual leucocytes and stromal cells, (ii) the contribution of trogocytosis in HLA-G expression on decidual cells, (iii) its interaction with the ILT2, ILT4 and KIR2DL4 receptors, (iv) the link between HLA-G polymorphism and pregnancy disorders, and (v) the expression of newly-described HLA-G isoforms at the maternal-fetal interface.
非经典 HLA I 类分子 HLA-G 在滋养层细胞中表达，有助于母体-胎儿耐受。HLA-G 参与了滋养层细胞浸润、子宫血管重塑和局部免疫抑制状态的维持的调控。因此，理解母体-胎儿界面的 HLA-G 生物学是生殖的一个关键问题。在这方面，我们在这里综述：（i）HLA-G 对蜕膜白细胞和基质细胞的影响，（ii）trogoctosis 在蜕膜细胞 HLA-G 表达中的贡献，（iii）与 ILT2、ILT4 和 KIR2DL4 受体的相互作用，（iv）HLA-G 多态性与妊娠疾病的关系，以及（v）新描述的 HLA-G 同种型在母体-胎儿界面的表达。
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