免疫检查点抑制剂治疗引起的免疫介导性结肠炎后并发的异时性食管溃疡：病例报告及文献复习。

Department of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital, Japan.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Japan.

Intern Med. 2021 Sep 1;60(17):2783-2791. doi: 10.2169/internalmedicine.6606-20. Epub 2021 Mar 22.

Although cases of gastrointestinal toxicity of pembrolizumab have been reported, cases of acute immune-mediated colitis accompanied with metachronous esophageal disorders (esophagitis and ulcer) are rare. We herein report a case of acute colitis and metachronous esophageal ulcers due to an immune-related adverse event following concomitant pembrolizumab chemotherapy for lung adenocarcinoma. To our knowledge, there have so far been no reports of cases in which both acute immune-mediated colitis and metachronous esophageal ulcers developed. We therefore report the details of this case along with a review of the pertinent literature.

虽然已有报道称 pembrolizumab 会引起胃肠道毒性，但伴有同时性食管疾病（食管炎和溃疡）的急性免疫介导性结肠炎较为罕见。本文报告了一例肺腺癌患者在接受 pembrolizumab 化疗的同时发生免疫相关不良事件导致的急性结肠炎和同时性食管溃疡。据我们所知，目前尚无同时发生急性免疫介导性结肠炎和同时性食管溃疡的病例报告。因此，我们报告了该病例的详细情况并复习了相关文献。