Zhang Weiqiao, Ge Fei, Lian Chaohui, Xia Ruiqiang, Zhang Bing
Department of Anesthesiology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China (mainland).
Department of Anesthesiology, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China (mainland).
Med Sci Monit. 2021 Mar 22;27:e928750. doi: 10.12659/MSM.928750.
BACKGROUND Hypoxic hypoperfusion injury in the brain is a cause of potential injury and even death in the growth period of newborns. Therefore, monitoring regional cerebral oxygen saturation (CrSO₂) during this period is particularly important. This observational clinical study from a single center aimed to investigate the factors associated with CrSO₂ in full-term newborn infants during birth transition. MATERIAL AND METHODS We enrolled 84 full-term newborn infants delivered by cesarean section. We started the stopwatch with the obstetrician clamping the newborns' umbilical cords and recorded the values of newborns' CrSO₂, pulse oxygen saturation (SpO₂), pulse rate (PR), end-tidal carbon dioxide (EtCO₂), and respiratory rate (RR) at 2 min, 5 min, and 10 min. We weighed the newborns before they left the operating room and used statistical methods to compare the correlation between each observation factor. RESULTS Pearson correlation coefficients between CrSO₂ and SpO₂ measured at 2 min, 5 min, and 10 min were 0.491, 0.599, and 0.587, respectively (P<0.01). Pearson correlation coefficients between CrSO₂ and EtCO₂ measured at 2 min, 5 min, and 10 min were -0.304, -0.443, and -0.243, respectively (P<0.05). Regardless of a newborn's weight, PR, or RR, the correlation between any of those factors and the value of CrSO₂ measured at the corresponding time point had no significance (P>0.05). CONCLUSIONS This study showed a correlation between CrSO₂ and SpO₂ and CrSO₂ and EtCO₂ during birth transition of full-term infants delivered by elective cesarean section, but CrSO₂ had no significant correlation with neonatal weight, PR, or RR.
脑缺氧性低灌注损伤是新生儿生长发育过程中潜在的损伤甚至死亡原因。因此，在此期间监测局部脑氧饱和度（CrSO₂）尤为重要。这项来自单一中心的观察性临床研究旨在调查足月新生儿出生过渡期间与CrSO₂相关的因素。
我们纳入了84例剖宫产分娩的足月新生儿。在产科医生夹住新生儿脐带时启动秒表，并记录新生儿在2分钟、5分钟和10分钟时的CrSO₂、脉搏血氧饱和度（SpO₂）、心率（PR）、呼气末二氧化碳（EtCO₂）和呼吸频率（RR）值。在新生儿离开手术室前称重，并使用统计方法比较各观察因素之间的相关性。
在2分钟、5分钟和10分钟时测量的CrSO₂与SpO₂之间的Pearson相关系数分别为0.491、0.599和0.587（P<0.01）。在2分钟、5分钟和10分钟时测量的CrSO₂与EtCO₂之间的Pearson相关系数分别为-0.304、-0.443和-0.243（P<0.05）。无论新生儿的体重、PR或RR如何，这些因素中的任何一个与相应时间点测量的CrSO₂值之间的相关性均无统计学意义（P>0.05）。
本研究表明，择期剖宫产分娩的足月婴儿在出生过渡期间CrSO₂与SpO₂以及CrSO₂与EtCO₂之间存在相关性，但CrSO₂与新生儿体重、PR或RR无显著相关性。
