Dean McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
School of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Eye (Lond). 2022 Mar;36(3):568-574. doi: 10.1038/s41433-021-01476-3. Epub 2021 Mar 21.
To evaluate the utility of dissolvable collagen punctal plugs (CPP) in reducing ocular surface irritation after intravitreal injections (IVI).
Sixty-four subjects in the experimental group received CPP after intravitreal injections. Sixty-two controls did not receive CPP. Reductions in the Ocular Surface Disease Index (OSDI) and Standardized Patient Evaluation of Eye Dryness II (SPEED II) scores were analysed.
Dry eye symptoms, as measured by reductions from the pre- to post-injection OSDI (p = 0.137) and SPEED II (p = 0.381) scores, did not significantly differ between the two groups. In sub-group analysis, patients with objective findings of dry eyes had significant improvement in their symptoms (p = 0.046) with CPP. The effect of CPP is not significant in those without dry eyes (p = 0.27).
CPPs were not effective in reducing post-injection ocular irritation in patients with no or only mild dry eye symptoms. CPPs improved patients' post-injection comfort levels in those who had moderate-to-severe symptoms and objective findings of dry eye. Though costly CPP could be considered in selective patients. A standardized eye rinse could be a simple, efficacious, and cost-effective way to reduce post-injection ocular irritation; however, more studies are needed.
评估可溶解胶原性泪点塞（CPP）在减少玻璃体腔内注射（IVI）后眼表刺激的效果。
实验组 64 例患者在玻璃体腔内注射后接受 CPP 治疗，对照组 62 例患者未接受 CPP 治疗。分析眼表疾病指数（OSDI）和标准化患者眼干燥评估 II （SPEED II）评分的降低情况。
两组之间，通过注射前后 OSDI（p=0.137）和 SPEED II（p=0.381）评分降低情况来衡量的干眼症状，没有明显差异。在亚组分析中，有客观干眼发现的患者，其症状有明显改善（p=0.046）。而在没有干眼的患者中，CPP 的效果并不显著（p=0.27）。
CPP 对于没有或仅有轻度干眼症状的患者，在减少注射后眼部刺激方面无效。对于有中重度症状和客观干眼发现的患者，CPP 可提高患者的注射后舒适度。尽管 CPP 价格昂贵，但可以考虑在选择性患者中使用。标准化的眼部冲洗可能是一种简单、有效且具有成本效益的方法来减少注射后的眼部刺激；然而，还需要更多的研究。
