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[儿童及青少年癌症患者的发热性中性粒细胞减少症]

[Febrile neutropenia in pediatric and adolescent cancer patients].

作者信息

Bochennek K, Simon A, Laws H-J, Groll A H, Lehrnbecher T

机构信息

Pädiatrische Hämatologie und Onkologie, Klinik für Kinder- und Jugendmedizin, Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt, Deutschland.

Pädiatrische Hämatologie und Onkologie, Kinderklinik, Universitätsklinikum Homburg, Homburg, Deutschland.

出版信息

Monatsschr Kinderheilkd. 2021;169(5):443-450. doi: 10.1007/s00112-021-01146-4. Epub 2021 Mar 15.

DOI:10.1007/s00112-021-01146-4
PMID:33746294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7959272/
Abstract

Febrile neutropenia is the most common potential emergency situation in children and adolescents with cancer. The host response of these patients is severely compromised by treatment-induced immunosuppression resulting in a lack of important defence mechanisms, so that bacterial infections and in certain risk groups also fungal infections can be life threatening. As the clinical course of these infectious complications may be rapid and fatal, early antibiotic treatment can save lives. This article aims to raise awareness to this emergency situation and gives an overview of the management of pediatric cancer patients with febrile neutropenia.

摘要

发热性中性粒细胞减少是癌症患儿和青少年中最常见的潜在紧急情况。这些患者的宿主反应因治疗引起的免疫抑制而严重受损，导致缺乏重要的防御机制，因此细菌感染以及在某些风险组中真菌感染也可能危及生命。由于这些感染并发症的临床过程可能迅速且致命，早期抗生素治疗可以挽救生命。本文旨在提高对这种紧急情况的认识，并概述发热性中性粒细胞减少的儿科癌症患者的管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91b/7959272/d8b9fdc33cf0/112_2021_1146_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91b/7959272/43097b2f2463/112_2021_1146_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91b/7959272/ab56e3409791/112_2021_1146_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91b/7959272/d8b9fdc33cf0/112_2021_1146_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91b/7959272/43097b2f2463/112_2021_1146_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91b/7959272/ab56e3409791/112_2021_1146_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91b/7959272/d8b9fdc33cf0/112_2021_1146_Fig3_HTML.jpg

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Lancet Oncol. 2021 Jun;22(6):e270-e280. doi: 10.1016/S1470-2045(20)30725-7. Epub 2021 Mar 31.
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8th European Conference on Infections in Leukaemia: 2020 guidelines for the diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or post-haematopoietic cell transplantation.第8届欧洲白血病感染会议：2020年癌症患儿或造血干细胞移植后患儿侵袭性真菌病的诊断、预防和治疗指南
Lancet Oncol. 2021 Jun;22(6):e254-e269. doi: 10.1016/S1470-2045(20)30723-3. Epub 2021 Mar 31.
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Association Between Depth of Neutropenia and Clinical Outcomes in Febrile Pediatric Cancer and/or Patients Undergoing Hematopoietic Stem-cell Transplantation.中性粒细胞减少症的深度与发热性儿科癌症和/或接受造血干细胞移植患者的临床结局之间的关联。
Pediatr Infect Dis J. 2020 Jul;39(7):628-633. doi: 10.1097/INF.0000000000002641.
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Blood Stream Infections and Antibiotic Utilization in Pediatric Leukemia Patients With Febrile Neutropenia.儿童急性淋巴细胞白血病伴发热性中性粒细胞减少症患者的血流感染与抗生素使用情况
J Pediatr Hematol Oncol. 2019 May;41(4):251-255. doi: 10.1097/MPH.0000000000001279.
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Fluoroquinolone prophylaxis during neutropenia: what can we expect nowadays?中性粒细胞减少期间的氟喹诺酮类药物预防：如今我们能期待什么？
Clin Microbiol Infect. 2018 Jul;24(7):678-679. doi: 10.1016/j.cmi.2018.02.031. Epub 2018 Mar 13.
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