Wang Zhu, Zhang Ying, Zhang Jianwen, Deng Qiong, Liang Hui
Department of Urology, People's Hospital of Longhua, Southern Medical University, Shenzhen, Guangdong 518109, P.R. China.
Oncol Lett. 2021 May;21(5):356. doi: 10.3892/ol.2021.12617. Epub 2021 Mar 4.
Hepatocyte nuclear receptor 4 α (HNF4α) is known to be a master transcription regulator of gene expression in multiple biological processes, particularly in liver development and liver function. To date, the function of HNF4α in human cancers has been widely investigated; however, the critical roles of HNF4α in tumorigenesis remain unclear. Numerous controversies exist, even in studies from different research groups but on the same type of cancer. In the present review, the critical roles of HNF4α in tumorigenesis will be summarized and discussed. Furthermore, HNF4α expression profile and alterations will be examined by pan-cancer analysis through bioinformatics, in order to provide a better understanding of the functional roles of this gene in human cancers.
已知肝细胞核受体4α（HNF4α）是多种生物学过程中基因表达的主要转录调节因子，尤其是在肝脏发育和肝功能方面。迄今为止，HNF4α在人类癌症中的功能已得到广泛研究；然而，HNF4α在肿瘤发生中的关键作用仍不清楚。即使在不同研究小组针对同一类型癌症进行的研究中，也存在许多争议。在本综述中，将总结和讨论HNF4α在肿瘤发生中的关键作用。此外，将通过生物信息学的泛癌分析来研究HNF4α的表达谱和改变，以便更好地了解该基因在人类癌症中的功能作用。
