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肝细胞癌合并动静脉瘘的影像学诊断与介入治疗。

Imaging Diagnosis and Interventional Treatment for Hepatocellular Carcinoma Combined with Arteriovenous Fistula.

机构信息

The Second Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China.

Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou, China.

出版信息

J Healthc Eng. 2021 Mar 4;2021:6651236. doi: 10.1155/2021/6651236. eCollection 2021.

Abstract

In order to explore the imaging diagnosis methods and interventional treatment effects of hepatocellular carcinoma combined with hepatic arteriovenous fistula (HAVF), a total of 120 patients, who were diagnosed as hepatic carcinoma with arteriovenous shunting and underwent medical imaging diagnosis and interventional surgery therapy at a designated hospital by this study from December 2014 to December 2018, were chosen as study subjects. Digital subtraction angiography was performed to analyze the imaging features of hepatocellular carcinoma combined with HAVF in each patient; then, according to these imaging diagnosis results, gelatin sponge or coil was used to block the fistula; mitomycin, carboplatin powder, and lipiodol mixed emulsion was combined or separately utilized for hepatic tumor embolization, in which iodized oil embolization chemotherapy was used for patients with mild paralysis; gelatin sponge granule embolization chemotherapy was used for moderate paralysis patients at their first intervention, and, after about 1 month, if the sputum disappeared, iodized oil embolization was used again; and hepatic arterial infusion chemotherapy was used only for patients with severe paralysis. The results show that the central type of HAVF is characterized by early angiography of portal vein and large branches and tumor staining after portal vein's angiography; the peripheral type of HAVF is characterized by portal vein branching in hepatic tumor and double rail sign accompanied by the arterial branch; 112 cases of patients completed embolization chemotherapy; 8 cases of patients only received chemotherapy perfusion; in 109 cases of patients sputum disappeared or shunt decreased at first treatment; and in 113 cases of patients iodine oil was well deposited or the tumor was stably reduced; most of the symptoms of refractory ascites, diarrhea, and upper gastrointestinal bleeding were controlled or improved, and there were no complications such as pulmonary embolism and hepatic failure. Therefore, HAVF increases the difficulty of interventional therapy, but, as long as the positive and appropriate treatment measures are taken, it can still achieve better curative effect without serious complications, which can effectively alleviate the clinical symptoms of patients and improve the quality of life of patients. The results of this study provide a reference for the further researches on imaging diagnosis and interventional treatment for hepatocellular carcinoma combined with arteriovenous fistula.

摘要

为了探讨肝癌合并肝动静脉瘘(HAVF)的影像诊断方法和介入治疗效果,本研究选取了 2014 年 12 月至 2018 年 12 月在指定医院经医学影像诊断和介入手术治疗确诊为肝癌伴动静脉分流的 120 例患者作为研究对象。对每位患者进行数字减影血管造影,分析肝癌合并 HAVF 的影像特征;然后根据这些影像诊断结果,使用明胶海绵或弹簧圈阻断瘘管;将丝裂霉素、卡铂粉和碘油混合乳剂联合或单独用于肝肿瘤栓塞,对于轻度瘫痪的患者采用碘油栓塞化疗;对于中度瘫痪的患者,在第一次介入治疗时采用明胶海绵颗粒栓塞化疗,约 1 个月后,如果痰消失,再次使用碘油栓塞;对于重度瘫痪的患者,仅采用肝动脉灌注化疗。结果显示,中央型 HAVF 的特点是门静脉早期造影及门静脉造影后大分支和肿瘤染色;周围型 HAVF 的特点是肝肿瘤分支的门静脉及双轨征伴有动脉分支;112 例患者完成栓塞化疗;8 例患者仅接受化疗灌注;109 例患者首次治疗时痰消失或分流减少;113 例患者碘油沉积良好或肿瘤稳定缩小;大部分难治性腹水、腹泻和上消化道出血等症状得到控制或改善,未发生肺栓塞和肝功能衰竭等并发症。因此,HAVF 增加了介入治疗的难度,但只要采取积极、恰当的治疗措施,仍能取得较好的疗效,且无严重并发症,可有效缓解患者的临床症状,提高患者的生活质量。本研究结果为肝癌合并动静脉瘘的影像诊断和介入治疗提供了参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d3b/7952172/57abe905fe9f/JHE2021-6651236.001.jpg

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