新冠疫情凸显了生物医学研究中的模式困境。
COVID-19 highlights the model dilemma in biomedical research.
作者信息
Adhikary Partho Protim, Ul Ain Qurrat, Hocke Andreas Christian, Hedtrich Sarah
机构信息
Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC Canada.
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany.
出版信息
Nat Rev Mater. 2021;6(5):374-376. doi: 10.1038/s41578-021-00305-z. Epub 2021 Mar 17.
Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. Interspecies-related differences, such as host specificity, divergent immune responses, or the unavailability of species-specific reagents hamper the research. Human-based models, such as micro-engineered multi-organs-on-chip, may hold the solution.
世界各地的科学家都在努力寻找合适的动物模型来研究新冠病毒感染。种间差异，如宿主特异性、不同的免疫反应或缺乏物种特异性试剂，阻碍了这项研究。基于人类的模型，如微工程多器官芯片，可能是解决办法。
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