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了解宿主针对新型冠状病毒感染和新冠肺炎发病机制的固有免疫反应。

Understanding the Host Innate Immune Responses against SARS-CoV-2 Infection and COVID-19 Pathogenesis.

作者信息

Kang Yeon-Woo, Park Subin, Lee Kun-Joo, Moon Dain, Kim Young-Min, Lee Seung-Woo

机构信息

Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.

Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.

出版信息

Immune Netw. 2021 Feb 26;21(1):e1. doi: 10.4110/in.2021.21.e1. eCollection 2021 Feb.

DOI:10.4110/in.2021.21.e1
PMID:33728094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7937512/
Abstract

The emergence of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a significant health concern worldwide. Undoubtedly, a better understanding of the innate and adaptive immune responses against SARS-CoV-2 and its relationship with the coronavirus disease 2019 (COVID-19) pathogenesis will be the sole basis for developing and applying therapeutics. This review will summarize the published results that relate to innate immune responses against infections with human coronaviruses including SARS-CoV-1 and SARS-CoV-2 in both humans and animal models. The topics encompass the innate immune sensing of the virus to the dysregulation of various innate immune cells during infection and disease progression.

摘要

一种新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行的出现已成为全球重大的健康问题。毫无疑问，更好地了解针对SARS-CoV-2的先天性和适应性免疫反应及其与2019冠状病毒病（COVID-19）发病机制的关系将是开发和应用治疗方法的唯一基础。本综述将总结已发表的有关人类和动物模型中针对包括SARS-CoV-1和SARS-CoV-2在内的人类冠状病毒感染的先天性免疫反应的结果。主题涵盖病毒的先天性免疫感知到感染和疾病进展过程中各种先天性免疫细胞的失调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60b/7937512/c0dd6f35d2f8/in-21-e1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60b/7937512/5adf9ea4b474/in-21-e1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60b/7937512/c0dd6f35d2f8/in-21-e1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60b/7937512/5adf9ea4b474/in-21-e1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c60b/7937512/c0dd6f35d2f8/in-21-e1-g002.jpg

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