玻璃体切除联合硅油填充术后前房内注射抗血管内皮生长因子治疗晚期新生血管性青光眼
Intracameral anti-VEGF injection for advanced neovascular glaucoma after vitrectomy with silicone oil tamponade.
作者信息
Bai Ling, Tariq Farheen, He Yi-Dan, Zhang Shu, Wang Feng
机构信息
Department of Ophthalmology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710003, Shaanxi Province, China.
Experimental Teaching Center for Clinical Skills, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710003, Shaanxi Province, China.
出版信息
Int J Ophthalmol. 2021 Mar 18;14(3):456-460. doi: 10.18240/ijo.2021.03.20. eCollection 2021.
AIM
To evaluate the effect of intracameral injection of conbercept for the treatment of advanced neovascular glaucoma (NVG) after vitrectomy with silicone oil tamponade.
METHODS
Conbercept 0.5 mg/0.05 mL was injected into the anterior chamber of 5 eyes, which had developed advanced NVG after vitrectomy with silicone oil tamponade. Then, trabeculectomy with mitomycin C and pan-retinal photocoagulation (PRP) or extra-PRP were conducted within 2d. The follow-up time was 6mo. Best-corrected visual acuity (BCVA), intraocular pressure (IOP), neovascularization of iris (NVI) were recorded before and after treatment.
RESULTS
Within 2d after injection, IOP control, and NVI regression were optimal for trabeculectomy. Hyphema occurred in one eye in the process of injection. But none of them present hyphema after trabeculectomy. At the end of follow-up time, all eyes had improved BCVA, well-controlled IOP, and completely regressed NVI.
CONCLUSION
Intracameral injection of conbercept is safe and effective in the treatment of patients with advanced NVG after vitrectomy with silicone oil tamponade. Within 2d after injection is the optimal time window for trabeculectomy, which can maximally reduce the risk of perioperative hyphema.
目的
评估前房注射康柏西普治疗玻璃体切除联合硅油填充术后晚期新生血管性青光眼（NVG）的效果。
方法
对5例玻璃体切除联合硅油填充术后发生晚期NVG的患眼，前房注射0.5 mg/0.05 mL康柏西普，然后在2天内进行丝裂霉素C小梁切除术及全视网膜光凝（PRP）或补充PRP。随访时间为6个月。记录治疗前后的最佳矫正视力（BCVA）、眼压（IOP）、虹膜新生血管（NVI）情况。
结果
注射后2天内，小梁切除术的眼压控制和NVI消退效果最佳。注射过程中有1只眼发生前房积血，但小梁切除术后均无前房积血。随访结束时，所有患眼的BCVA均提高，眼压控制良好，NVI完全消退。
结论
前房注射康柏西普治疗玻璃体切除联合硅油填充术后晚期NVG患者安全有效。注射后2天内是小梁切除术的最佳时间窗，可最大程度降低围手术期前房积血的风险。
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