Monnappa Amrutha Balliamada, Manjunatha Jamballi Gangadharappa, Bhatt Aarti Sripathi, Malini Kodi
Department of Chemistry, FMKMC College, Madikeri, Constituent College of Mangalore University, Karnataka, India.
Department of Chemistry, N.M.A.M. Institute of Technology, (Visvesvaraya Technological University, Belgavi) Nitte, 574110, Udupi District, Karnataka, India.
Adv Pharm Bull. 2021 Jan;11(1):111-119. doi: 10.34172/apb.2021.012. Epub 2020 Nov 7.
Isatin (IS) is a synthetically significant heterocyclic moiety with an influential pharmacodynamic indole nucleus and hence the electrocatalytic property of has been investigated. The electrochemical analysis was demonstrated by cyclic voltammetry (CV) in the potential window of 0.2 V to 1.4 V using sodium dodecyl sulfate (SDS) modified carbon nano tube paste electrode (SDSMCNTPE) over a pH range of 6 to 8.5 in 0.2 M phosphate buffer solution (PBS). Surface morphology was studied by using Field emission-scanning electron microscopy (FESEM). The CV study discloses that under ideal condition oxidation of IS arises at a potential of 0.970 V accompanied with an exceptional stability, selectivity and sensitivity for the resultant SDSMCNTPE contrasting to bare carbon nano tube paste electrode (BCNTPE). Individual parameters like electrode surface area, effect of surfactant, detection limit, simultaneous detection of IS and resorcinol (RC) were studied at a scan rate of 0.1 V/s. Scan rate study uncovers the process is diffusion controlled. The oxidation peak current amplified linearly with the surge in concentration of IS under ideal condition. Detection limit (LOD) and limit of quantification (LOQ) in the solution of optimum pH (7.5) at a scan rate of 0.100V/s is 2.4×10 M and 8.2 × 10 M respectively. The proposed electrode portrays excellent repeatability, reproducibility and reliability to resistant electrode fouling.
异吲哚酮（IS）是一种具有重要合成意义的杂环部分，带有具有影响力的药效吲哚核，因此对其电催化性能进行了研究。使用十二烷基硫酸钠（SDS）修饰的碳纳米管糊电极（SDSMCNTPE），在0.2 M磷酸盐缓冲溶液（PBS）中，于pH值6至8.5的范围内，通过循环伏安法（CV）在0.2 V至1.4 V的电位窗口中进行电化学分析。使用场发射扫描电子显微镜（FESEM）研究表面形态。CV研究表明，在理想条件下，IS的氧化发生在0.970 V的电位，与裸碳纳米管糊电极（BCNTPE）相比，所得SDSMCNTPE具有出色的稳定性、选择性和灵敏度。以0.1 V/s的扫描速率研究了诸如电极表面积、表面活性剂的影响、检测限、IS和间苯二酚（RC）的同时检测等各个参数。扫描速率研究表明该过程受扩散控制。在理想条件下，氧化峰电流随IS浓度的增加呈线性放大。在最佳pH值（7.5）的溶液中，以0.100V/s的扫描速率时，检测限（LOD）和定量限（LOQ）分别为2.4×10 M和8.2×10 M。所提出的电极具有出色的重复性、再现性和抗电极污染的可靠性。
