Aduhene Albert Gyapong, Cui Hongliang, Yang Hongyi, Liu Chengwei, Sui Guangchao, Liu Changli
Key Laboratory of Saline-Alkali Vegetation Ecology Restoration, Northeast Forestry University, Ministry of Education, Harbin, China.
College of Life Sciences, Northeast Forestry University, Harbin, China.
Front Bioeng Biotechnol. 2021 Mar 4;9:646995. doi: 10.3389/fbioe.2021.646995. eCollection 2021.
Many single-use non-degradable plastics are a threat to life today, and several polyhydroxyalkanoates (PHAs) biopolymers have been developed in the bioplastic industry to place petrochemical-based plastics. One of such is the novel biomaterial poly(3-hydroxypropionate) [poly(3HP)] because of its biocompatibility, biodegradability, and high yield synthesis using engineered strains. To date, many bio-polymer-based functional composites have been developed to increase the value of raw microbial-biopolymers obtained from cheap sources. This review article broadly covers poly(3HP), a comprehensive summary of critical biosynthetic production pathways comparing the yields and titers achieved in different Microbial cell Factories. This article also provides extensive knowledge and highlights recent progress on biosensors' use to optimize poly(3HP) production, some bacteria host adopted for production, chemical and physical properties, life cycle assessment for poly(3HP) production using corn oil as carbon source, and some essential medical applications of poly(3HP).
如今，许多一次性不可降解塑料对生命构成威胁，生物塑料行业已开发出几种聚羟基脂肪酸酯（PHA）生物聚合物来替代石化基塑料。其中一种新型生物材料是聚（3-羟基丙酸酯）[聚（3HP）]，因其具有生物相容性、可生物降解性以及使用工程菌株进行高产率合成的特性。迄今为止，已开发出许多基于生物聚合物的功能复合材料，以提高从廉价来源获得的原始微生物生物聚合物的价值。这篇综述文章广泛涵盖了聚（3HP），全面总结了关键生物合成生产途径，并比较了在不同微生物细胞工厂中所实现的产量和滴度。本文还提供了丰富的知识，并突出了生物传感器用于优化聚（3HP）生产的最新进展、一些用于生产的细菌宿主、化学和物理性质、以玉米油为碳源生产聚（3HP）的生命周期评估以及聚（3HP）的一些重要医学应用。
