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在退行性关节疾病背景下,用于原发性膝关节感染的可活动型与静态间隔物对比研究

Articulating vs Static Spacers for Native Knee Infection in the Setting of Degenerative Joint Disease.

作者信息

Hooper Jessica, Arora Prerna, Kappagoda Shanthi, Huddleston James I, Goodman Stuart B, Amanatullah Derek F

机构信息

Department of Orthopaedic Surgery, Stanford Medicine, Redwood City, CA, USA.

出版信息

Arthroplast Today. 2021 Mar 11;8:138-144. doi: 10.1016/j.artd.2021.01.009. eCollection 2021 Apr.

Abstract

BACKGROUND

Patients with advanced knee arthritis who develop a septic joint are not adequately treated with irrigation and debridement and intravenous antibiotics because of antecedent cartilage damage. The gold standard treatment has been a 2-stage approach. The periprosthetic joint infection literature has demonstrated the superiority of articulating spacers, and metal-on-poly (MOP) spacers are being used with increasing frequency. The purpose of this study was to compare the postoperative outcomes of patients with infected, arthritic knees treated by a 2-stage approach to those of patients who received single-stage treatment with a MOP spacer.

METHODS

Sixteen patients with native knee septic arthritis treated with an antibiotic spacer between 1998 and 2019 were reviewed. Demographic data, clinical data, knee motion, Knee Society score, Timed-Up-and-Go, and pain scores were collected. Survivorship of final implants was compared.

RESULTS

Six of 16 knees (38%) received single-stage treatment, and 10 received 2-stage treatment (62%). Five of 6 MOP spacers (83%) were retained at a mean follow-up of 3 ± 1.2 years. Nine of 10 (90%) receiving static spacers had subsequent reconstruction, with 9 (100%) surviving at mean follow-up of 7 ± 3.2 years. The patients who received MOP spacers trended toward greater terminal flexion, higher Knee Society score, and faster Timed-Up-and-Go at final follow-up.

CONCLUSION

Infection in a native, arthritic knee may be effectively treated using single-stage MOP spacer. Postoperative outcomes of single-stage MOP spacers compare favorably to staged static spacers and with those undergoing revision surgery for other indications. Longer follow-up is needed to evaluate durability of MOP spacers.

摘要

背景

晚期膝关节炎患者发生化脓性关节时,由于先前存在的软骨损伤,单纯的冲洗清创术和静脉使用抗生素治疗并不充分。金标准治疗方法一直是两阶段治疗。人工关节周围感染的文献表明,活动型间隔器具有优越性,金属对聚乙烯(MOP)间隔器的使用频率越来越高。本研究的目的是比较采用两阶段治疗方法的感染性膝关节炎患者与接受MOP间隔器单阶段治疗患者的术后结果。

方法

回顾了1998年至2019年间16例采用抗生素间隔器治疗的原发性膝关节化脓性关节炎患者。收集了人口统计学数据、临床数据、膝关节活动度、膝关节协会评分、定时起立行走测试结果和疼痛评分。比较最终植入物的生存率。

结果

16例膝关节中有6例(38%)接受了单阶段治疗,10例接受了两阶段治疗(62%)。6个MOP间隔器中有5个(83%)在平均3±1.2年的随访中得以保留。接受静态间隔器治疗的10例患者中有9例(90%)随后进行了重建,其中9例(100%)在平均7±3.2年的随访中存活。接受MOP间隔器治疗的患者在最终随访时,其终末屈曲度、膝关节协会评分更高,定时起立行走测试速度更快。

结论

原发性膝关节炎合并感染可采用单阶段MOP间隔器有效治疗。单阶段MOP间隔器的术后结果与分期静态间隔器以及因其他适应证接受翻修手术的患者相比具有优势。需要更长时间的随访来评估MOP间隔器的耐用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97af/7966924/98f49f4a895a/gr1.jpg

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