Marini G, Imeri L, Mancia M
Istituto di Fisiologica Umana II, Milano, Italy.
Neurosci Lett. 1988 Feb 29;85(2):223-7. doi: 10.1016/0304-3940(88)90355-2.
Bilateral lesions of medialis dorsalis (MD) thalamic nuclei in chronically implanted cats disrupt the sleep-waking cycle by inducing a reduction of both slow-wave and desynchronized sleep and a corresponding increase of wakefulness. Bilateral lesions of the anterior thalamic group produce some postural deficits but no changes in the percentage of sleep and wakefulness. The hypothesis that MD lesions alter the sleep processes by interrupting an anterior forebrain-MD-cortical link has been put forward.
在长期植入电极的猫中，双侧背内侧丘脑核（MD）损伤会导致慢波睡眠和去同步化睡眠减少，觉醒相应增加，从而扰乱睡眠-觉醒周期。丘脑前组的双侧损伤会导致一些姿势缺陷，但睡眠和觉醒的百分比没有变化。有人提出了一种假说，即MD损伤通过中断前脑-MD-皮质联系来改变睡眠过程。
