Li Yonghao, Dahal Dipendra, Abeywickrama Chathura S, Pang Yi
Department of Chemistry, University of Akron, Akron, Ohio 44325, United States.
Maurice Morton Institute of Polymer Science, University of Akron, Akron, Ohio 44325, United States.
ACS Omega. 2021 Mar 4;6(10):6547-6553. doi: 10.1021/acsomega.0c06252. eCollection 2021 Mar 16.
In this review, we will summarize our recent progress in the design and application of novel organic sensors with emission in the near-infrared region (600-900 nm). By coupling different functional groups with excited-state intramolecular proton transfer (ESIPT) segments, new probes are developed to achieve a large Stokes shift, high sensitivity, and selectivity and to tune the emission toward the near-infrared region. The developed probes exhibit attractive optical properties for bioimaging and environmental science applications. In addition, we further discuss the photophysical properties of ESIPT dyes and how their fluorescence could be affected by structural/environmental factors, which should be considered during the development of robust ESIPT-based fluorescence probes. Their potential applications as imaging reagents are illustrated for intracellular membranes, mitochondria, lysosomes, and some biomolecules.
在本综述中，我们将总结我们在近红外区域（600 - 900 nm）发光的新型有机传感器的设计与应用方面的最新进展。通过将不同的官能团与激发态分子内质子转移（ESIPT）片段相结合，开发出了新的探针，以实现大斯托克斯位移、高灵敏度和选择性，并将发射调向近红外区域。所开发的探针在生物成像和环境科学应用中展现出有吸引力的光学性质。此外，我们进一步讨论了ESIPT染料的光物理性质以及其荧光如何受到结构/环境因素的影响，这在开发稳健的基于ESIPT的荧光探针时应予以考虑。还展示了它们作为成像试剂在细胞内膜、线粒体、溶酶体和一些生物分子方面的潜在应用。
