血管发育中的周细胞
Pericytes in Vascular Development.
作者信息
Payne Laura Beth, Hoque Maruf, Houk Clifton, Darden Jordan, Chappell John C
机构信息
Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech-Carilion, Roanoke, VA 24016, USA.
Graduate Program in Translational Biology, Medicine and Health, Virginia Tech, Blacksburg, VA 24061, USA.
出版信息
Curr Tissue Microenviron Rep. 2020 Sep;1(3):143-154. doi: 10.1007/s43152-020-00014-9. Epub 2020 Jul 2.
Abstract
PURPOSE OF REVIEW
Pericytes are essential components of capillaries in many tissues and organs, contributing to vessel stability and integrity, with additional contributions to microvascular function still being discovered. We review current and foundational studies identifying pericyte differentiation mechanics and their roles in the earliest stages of vessel formation.
RECENT FINDINGS
Recent advances in pericyte-focused tools and models have illuminated critical aspects of pericyte biology including their roles in vascular development.Pericytes likely collaborate with endothelial cells undergoing vasculogenesis, initiating direct interactions during sprouting and intussusceptive angiogenesis. Pericytes also provide important regulation of vascular growth including mechanisms underlying vessel pruning, rarefaction, and subsequent regrowth.
摘要
综述目的
周细胞是许多组织和器官中毛细血管的重要组成部分，有助于血管的稳定性和完整性，其对微血管功能的其他作用仍在不断被发现。我们综述了当前及基础研究，这些研究确定了周细胞的分化机制及其在血管形成最早阶段的作用。
最新发现
以周细胞为重点的工具和模型的最新进展揭示了周细胞生物学的关键方面，包括它们在血管发育中的作用。周细胞可能与经历血管生成的内皮细胞协作，在出芽和套入式血管生成过程中启动直接相互作用。周细胞还对血管生长提供重要调节，包括血管修剪、稀疏化及随后再生的潜在机制。
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