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Pericytes in Microvessels: From "Mural" Function to Brain and Retina Regeneration.微血管周细胞：从“壁细胞”功能到脑和视网膜再生。
Int J Mol Sci. 2019 Dec 17;20(24):6351. doi: 10.3390/ijms20246351.
2
Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation.转录组分析揭示了微血管内皮细胞依赖性周细胞分化。
Sci Rep. 2019 Oct 30;9(1):15586. doi: 10.1038/s41598-019-51838-x.
3
Dynamic Interplay between Pericytes and Endothelial Cells during Sprouting Angiogenesis.血管生成中周细胞与内皮细胞的动态相互作用。
Cells. 2019 Sep 19;8(9):1109. doi: 10.3390/cells8091109.
4
Pericytes and Neurovascular Function in the Healthy and Diseased Brain.健康与患病大脑中的周细胞与神经血管功能
Front Cell Neurosci. 2019 Jun 28;13:282. doi: 10.3389/fncel.2019.00282. eCollection 2019.
5
The pericyte microenvironment during vascular development.血管发育过程中的周细胞微环境。
Microcirculation. 2019 Nov;26(8):e12554. doi: 10.1111/micc.12554. Epub 2019 May 27.
6
Microvascular bioengineering: a focus on pericytes.微血管生物工程：聚焦于周细胞
J Biol Eng. 2019 Mar 29;13:26. doi: 10.1186/s13036-019-0158-3. eCollection 2019.
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Human pluripotent stem cell-derived brain pericyte-like cells induce blood-brain barrier properties.人多能干细胞衍生的脑周细胞样细胞诱导血脑屏障特性。
Sci Adv. 2019 Mar 13;5(3):eaau7375. doi: 10.1126/sciadv.aau7375. eCollection 2019 Mar.
8
Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions.诱导人多能干细胞分化为中胚层和神经嵴来源的周细胞以研究血脑屏障相互作用。
Stem Cell Reports. 2019 Mar 5;12(3):451-460. doi: 10.1016/j.stemcr.2019.01.005. Epub 2019 Feb 7.
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Tunneling nanotubes evoke pericyte/endothelial communication during normal and tumoral angiogenesis.隧道纳米管在正常和肿瘤血管生成过程中引起周细胞/内皮细胞通讯。
Fluids Barriers CNS. 2018 Oct 5;15(1):28. doi: 10.1186/s12987-018-0114-5.
10
Excess vascular endothelial growth factor-A disrupts pericyte recruitment during blood vessel formation.过量的血管内皮生长因子 A 会破坏血管生成过程中的周细胞募集。
Angiogenesis. 2019 Feb;22(1):167-183. doi: 10.1007/s10456-018-9648-z. Epub 2018 Sep 20.

血管发育中的周细胞

Pericytes in Vascular Development.

作者信息

Payne Laura Beth, Hoque Maruf, Houk Clifton, Darden Jordan, Chappell John C

机构信息

Center for Heart and Reparative Medicine Research, Fralin Biomedical Research Institute at Virginia Tech-Carilion, Roanoke, VA 24016, USA.

Graduate Program in Translational Biology, Medicine and Health, Virginia Tech, Blacksburg, VA 24061, USA.

出版信息

Curr Tissue Microenviron Rep. 2020 Sep;1(3):143-154. doi: 10.1007/s43152-020-00014-9. Epub 2020 Jul 2.

DOI:10.1007/s43152-020-00014-9
PMID:33748774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7967288/
Abstract

PURPOSE OF REVIEW

Pericytes are essential components of capillaries in many tissues and organs, contributing to vessel stability and integrity, with additional contributions to microvascular function still being discovered. We review current and foundational studies identifying pericyte differentiation mechanics and their roles in the earliest stages of vessel formation.

RECENT FINDINGS

Recent advances in pericyte-focused tools and models have illuminated critical aspects of pericyte biology including their roles in vascular development.Pericytes likely collaborate with endothelial cells undergoing vasculogenesis, initiating direct interactions during sprouting and intussusceptive angiogenesis. Pericytes also provide important regulation of vascular growth including mechanisms underlying vessel pruning, rarefaction, and subsequent regrowth.

摘要

综述目的

周细胞是许多组织和器官中毛细血管的重要组成部分，有助于血管的稳定性和完整性，其对微血管功能的其他作用仍在不断被发现。我们综述了当前及基础研究，这些研究确定了周细胞的分化机制及其在血管形成最早阶段的作用。

最新发现

以周细胞为重点的工具和模型的最新进展揭示了周细胞生物学的关键方面，包括它们在血管发育中的作用。周细胞可能与经历血管生成的内皮细胞协作，在出芽和套入式血管生成过程中启动直接相互作用。周细胞还对血管生长提供重要调节，包括血管修剪、稀疏化及随后再生的潜在机制。