Grant Jelani K, Vincent Louis, Ebner Bertrand, Hurwitz Barry E, Alcaide Maria L, Martinez Claudia
Department of Medicine, University of Miami Miller School of Medicine/Jackson Memorial Hospital, Miami, Florida, USA.
Behavioral Medicine Research Center, University of Miami, Miami, Florida, USA.
J AIDS HIV Treat. 2020;2(2):68-74. doi: 10.33696/aids.2.010.
Persons living with HIV-1 (PLHIV) are at increased risk of cardiovascular complications in part due to the persistent inflammatory state despite viral suppression. SARS-CoV-2, the virus causing COVID-19, was declared a pandemic virus in March 2020, and caused over 30 million cases and 900,000 deaths worldwide to date. Individuals with COVID-19 are manifesting acute cardiovascular complications because of the inflammatory response associated with SARS-CoV-2 infection. It is not yet known whether having COVID-19 in the context of ongoing HIV-1 infection results in worse cardiovascular complications than in PLHIV who have not had COVID-19 infection. In this review, the potential for exacerbated cardiovascular manifestations in persons coinfected with HIV-1 and COVID-19 is considered.
人类免疫缺陷病毒1型感染者（PLHIV）患心血管并发症的风险增加，部分原因是尽管病毒得到抑制，但仍处于持续炎症状态。导致COVID-19的病毒SARS-CoV-2于2020年3月被宣布为大流行病毒，迄今为止在全球造成了超过3000万例病例和90万人死亡。COVID-19患者由于与SARS-CoV-2感染相关的炎症反应而出现急性心血管并发症。目前尚不清楚在持续的HIV-1感染背景下感染COVID-19是否会比未感染COVID-19的PLHIV导致更严重的心血管并发症。在这篇综述中，我们考虑了HIV-1和COVID-19合并感染者心血管表现加重的可能性。
