Department of Internal Medicine, University of California Riverside, Riverside, CA, USA.
Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.
Pediatr Dermatol. 2021 May;38(3):704-706. doi: 10.1111/pde.14576. Epub 2021 Mar 21.
As more therapeutic clinical trials focus on treatment of individual wounds in patients with recessive dystrophic epidermolysis bullosa, it has become crucial to understand the baseline clinical characteristics of these wounds. To investigate these features, we administered an RDEB-specific wound survey. Forty participants reported on location, size, pain, infection frequency, wound type, and duration of 189 wounds; a subset of 22 participants reported on pruritus in 63 wounds. Increased wound size was significantly associated with increased pain, increased pruritus, longer wound duration, increased infection frequency, and patients with mutations resulting in truncated type VII collagen.
随着越来越多的治疗性临床试验专注于治疗隐性营养不良型大疱性表皮松解症患者的个体伤口，了解这些伤口的基线临床特征变得至关重要。为了研究这些特征，我们进行了一项 RDEB 特异性伤口调查。40 名参与者报告了 189 处伤口的位置、大小、疼痛、感染频率、伤口类型和持续时间；22 名参与者的一部分报告了 63 处伤口的瘙痒情况。伤口大小的增加与疼痛、瘙痒、伤口持续时间、感染频率的增加以及导致 VII 型胶原蛋白截断突变的患者显著相关。
