Tianjin Engineering Research Center of Functional Fine Chemicals, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P. R. China.
Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, School of Science, Tianjin University, Tianjin, 300072, P. R. China.
Macromol Rapid Commun. 2021 May;42(9):e2100004. doi: 10.1002/marc.202100004. Epub 2021 Mar 22.
Molecular imprinting polymers (MIPs), generally considered as artificial mimics that are comparable to natural receptor, are polymers with tailor-made specific recognition sites complementary to the template molecules in shape and size. As a class of supramolecular compounds, cyclodextrins (CDs) are flourishing in the field of molecular imprinting with their unique structural properties. This review presents recent advances in application of MIPs based on CDs during the past five years. The discussion is grouped according to the different role of CDs in MIPs, that is, functional monomer, carrier modifier, etc. Main focus is the application of CD-based MIP on sample preparation, detection, and sensing. Additionally, drug delivery with CD-based MIP is also briefly discussed. Finally, challenges and future prospects of application of CDs in MIP are elaborated.
分子印迹聚合物（MIPs）通常被认为是与天然受体相当的人工模拟物，是一类具有定制特定识别位点的聚合物，其形状和大小与模板分子互补。作为超分子化合物的一类，环糊精（CDs）因其独特的结构特性，在分子印迹领域中得到了广泛的应用。本文综述了近五年来基于 CDs 的 MIPs 的应用进展。根据 CDs 在 MIPs 中的不同作用（如功能单体、载体修饰剂等）对讨论进行了分组。重点介绍了基于 CDs 的 MIP 在样品制备、检测和传感方面的应用。此外，还简要讨论了基于 CDs 的 MIP 在药物传递方面的应用。最后，阐述了 CDs 在 MIP 中应用的挑战和未来展望。
