Lay Sovichea, Ni Xiaofeng, Yu Haining, Shen Shengrong
Department of Food Science & Nutrition, Zhejiang University, Hangzhou, China.
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
J Sep Sci. 2016 Jun;39(12):2321-31. doi: 10.1002/jssc.201600003.
As a versatile tool in separation science, cyclodextrins and their derivatives, known as emerging functional monomers, have been used extensively in molecular imprinting techniques. The attributes of cyclodextrins and their derivatives are widely known to form host-guest inclusion complex processes between the polymer and template. The exploitation of the imprinting technique could produce a product of molecularly imprinted polymers, which are very robust with long-term stability, reliability, cost-efficiency, and selectivity. Hence, molecularly imprinted polymers have gained popularity in chemical separation and analysis. Molecularly imprinted polymers containing either cyclodextrin or its derivatives demonstrate superior binding effects for a target molecule. As noted in the previous studies, the functional monomers of cyclodextrins and their derivatives have been used in molecular imprinting for selective separation with a wide range of chemical compounds, including steroidals, amino acids, polysaccharides, drugs, plant hormones, proteins, pesticides, and plastic additives. Therefore, the main goal of this review is to illustrate the exotic applications of imprinting techniques employing cyclodextrins and their derivatives as single or binary functional monomers in synthesizing molecularly imprinted polymers in areas of separation science by reviewing some of the latest studies reported in the literature.
作为分离科学中的一种多功能工具，环糊精及其衍生物作为新兴的功能单体，已在分子印迹技术中得到广泛应用。环糊精及其衍生物的特性众所周知，它们能在聚合物与模板之间形成主客体包合络合过程。印迹技术的开发可以生产出分子印迹聚合物产品，这些聚合物具有很强的稳定性、可靠性、成本效益和选择性。因此，分子印迹聚合物在化学分离和分析中越来越受欢迎。含有环糊精或其衍生物的分子印迹聚合物对目标分子表现出优异的结合效果。如先前研究所述，环糊精及其衍生物的功能单体已用于分子印迹，以与包括甾体、氨基酸、多糖、药物、植物激素、蛋白质、农药和塑料添加剂在内的多种化合物进行选择性分离。因此，本综述的主要目的是通过回顾文献中报道的一些最新研究，阐述在分离科学领域中使用环糊精及其衍生物作为单一或二元功能单体合成分子印迹聚合物的印迹技术的奇特应用。
