Department of Radiology, Haydarpasa Numune Training and Research Hospital. Istanbul, Turkey.
Department of Pediatrics, Haydarpasa Numune Training and Research Hospital. Istanbul, Turkey.
Arch Argent Pediatr. 2021 Apr;119(2):114-122. doi: 10.5546/aap.2021.eng.114.
Childhood obesity can cause hyperlipidemia and hepatic steatosis at early age and chronic disease complications in adult life. We aimed to evaluate the relationship between abdominal subcutaneous fat thickness (ASFT) and hepatic steatosis, serum lipid and transaminase levels in obese children.
A retrospective study was conducted with children (aged 4-18 years) who presented to outpatient clinic due to obesity. Associations between ASFT as assessed by ultrasonography (US) and hepatic steatosis, alanine transaminase (ALT), aspartate transaminase (AST) and serum lipid profile were evaluated.
We identified 95 children, all of which were diagnosed as having hepatic steatosis; the most common type was grade 1 (73.6 %, n: 70), followed by grade 2 (21.1 %) and grade 3 (5.3 %). The mean values of midline and flank ASFT were measured as 38.48 ± 11.53 mm and 20.91 ± 8.00 mm in grade 1; 41.23 ± 10.03 and 19.84 ± 6.75 in grade 2 and 63.12 ± 12.08 and 23.22 ± 5.92 in grade 3 hepatic steatosis, respectively. Midline and flank ASFT correlated positively with triglycerides in grade 3 steatosis, while midline ASFT correlated with body mass index, total cholesterol, low-density lipoprotein cholesterol, and AST (r: 0.9; p: 0.037; r: 0.648, p: 0.001; r: 0.387, p: 0.001; r: 0.406, p: 0.001, r: 0.463, p: 0.001; respectively) in grade 1 steatosis.
ASFT as assessed by US may be of predictive value for hyperlipidemia in grade 3 and for hypercholesterolemia in grade 1 hepatic steatosis in obese children.
儿童肥胖可导致其在幼年时期出现高血脂和肝脂肪变性，并在成年后引发慢性疾病并发症。本研究旨在评估肥胖儿童的腹部皮下脂肪厚度（ASFT）与肝脂肪变性、血清脂质和转氨酶水平之间的关系。
本研究为回顾性研究，纳入因肥胖就诊于门诊的 4-18 岁儿童。通过超声（US）评估 ASFT 与肝脂肪变性、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和血清脂质谱之间的相关性。
共纳入 95 例肥胖儿童，所有儿童均被诊断为肝脂肪变性，最常见的类型为 1 级（73.6%，n=70），其次是 2 级（21.1%）和 3 级（5.3%）。1 级肝脂肪变性患者的中线和侧线 ASFT 平均值分别为 38.48±11.53mm 和 20.91±8.00mm，2 级分别为 41.23±10.03mm 和 19.84±6.75mm，3 级分别为 63.12±12.08mm 和 23.22±5.92mm。3 级肝脂肪变性中线和侧线 ASFT 与甘油三酯呈正相关，而中线 ASFT 与体重指数、总胆固醇、低密度脂蛋白胆固醇和 AST 呈正相关（r：0.9；p：0.037；r：0.648，p：0.001；r：0.387，p：0.001；r：0.406，p：0.001；r：0.463，p：0.001）。1 级肝脂肪变性患者中，ASFT 与总胆固醇和低密度脂蛋白胆固醇呈正相关。
US 评估的 ASFT 可能对 3 级肥胖儿童的高血脂和 1 级肝脂肪变性儿童的高胆固醇血症具有预测价值。
