Department of Radiology, University of Illinois at Chicago, Chicago, Illinois, USA.
Diagn Interv Radiol. 2012 May-Jun;18(3):282-7. doi: 10.4261/1305-3825.DIR.4958-11.2. Epub 2012 Jan 18.
To assess the relationship between body mass index (BMI), subcutaneous and intra-abdominal fat, liver density, and histopathologic hepatic steatosis.
In this retrospective study, 143 patients (male/female, 67/76; mean age, 50 years) underwent a non-targeted transjugular (n = 125) or percutaneous (n = 18) liver biopsy between 2006 and 2010. The biopsy indications included chronic liver parenchymal disease staging (n = 88), elevated enzymes (n = 39), or other reasons (n = 16). The BMI and non-contrast liver computed tomography liver density were recorded for each patient. The thicknesses of the anterior, posterior, and posterolateral subcutaneous fat, along with the intra-abdominal fat, were measured. The values were then correlated with histopathologic steatosis.
Of the patients, 47/143 (32%), 39/143 (28%), and 57/143 (40%) were normal weight, overweight, and obese, respectively. Steatosis was present in 13/47 (28%) of normal weight, 18/39 (46%) of overweight, and 38/57 (67%) of obese patients. Significant differences in BMI (26.7 kg/m(2) vs. 31.7 kg/ m2 vs. 35.0 kg/m(2), P < 0.001), liver density (52.8 HU vs. 54.4 HU vs. 42.0 HU, P < 0.001), anterior subcutaneous (1.8 cm vs. 2.4 cm vs. 2.9 cm, P < 0.001), posterolateral subcutaneous (2.8 cm vs. 3.2 cm vs. 4.4 cm, P < 0.004), posterior subcutaneous (1.9 cm vs. 2.5 cm vs. 3.4 cm, P < 0.001), and intra-abdominal fat thickness (1.1 cm vs. 1.3 cm vs. 1.4 cm, P < 0.013) were identified in patients with different degrees of steatosis (none, minimal to mild, moderate to severe, respectively). BMI (r = 0.37, P < 0.001) and the anterior subcutaneous fat (r = 0.30, P < 0.001) had a moderate correlation with the presence of liver steatosis. A combination of a BMI ≥ 32.0 kg/ m(2) and an anterior subcutaneous fat thickness ≥ 2.4 cm had a 40% sensitivity and 90% specificity for the identification of steatosis.
Increase in the anthropomorphic metrics of obesity is associated with an increased frequency of liver steatosis.
评估体重指数（BMI）、皮下和腹腔内脂肪、肝脏密度与组织病理学肝脂肪变性之间的关系。
在这项回顾性研究中，2006 年至 2010 年间共有 143 名患者（男/女，67/76；平均年龄 50 岁）接受了非靶向经颈静脉（n = 125）或经皮（n = 18）肝活检。活检指征包括慢性肝实质疾病分期（n = 88）、酶升高（n = 39）或其他原因（n = 16）。每位患者均记录了 BMI 和非对比肝脏计算机断层扫描（CT）肝脏密度。测量了前、后和后外侧皮下脂肪以及腹腔内脂肪的厚度。然后将这些值与组织病理学脂肪变性进行相关性分析。
143 名患者中，分别有 47/143（32%）、39/143（28%）和 57/143（40%）为正常体重、超重和肥胖。正常体重者中 13/47（28%）、超重者中 18/39（46%）和肥胖者中 38/57（67%）存在脂肪变性。BMI（26.7 kg/m2 vs. 31.7 kg/m2 vs. 35.0 kg/m2，P < 0.001）、肝脏密度（52.8 HU vs. 54.4 HU vs. 42.0 HU，P < 0.001）、前皮下脂肪（1.8 cm vs. 2.4 cm vs. 2.9 cm，P < 0.001）、后外侧皮下脂肪（2.8 cm vs. 3.2 cm vs. 4.4 cm，P < 0.004）、后皮下脂肪（1.9 cm vs. 2.5 cm vs. 3.4 cm，P < 0.001）和腹腔内脂肪厚度（1.1 cm vs. 1.3 cm vs. 1.4 cm，P < 0.013）在不同程度脂肪变性（无、轻度至中度、中度至重度）的患者中存在显著差异。BMI（r = 0.37，P < 0.001）和前皮下脂肪（r = 0.30，P < 0.001）与肝脏脂肪变性的存在具有中度相关性。BMI ≥ 32.0 kg/m2 和前皮下脂肪厚度≥2.4 cm 的组合对脂肪变性的识别具有 40%的敏感性和 90%的特异性。
肥胖人体测量学指标的增加与肝脏脂肪变性的发生率增加相关。
