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2 型糖尿病中糖尿病肾病的最佳早期诊断和监测:解决蛋白尿检测的障碍。

Optimal Early Diagnosis and Monitoring of Diabetic Kidney Disease in Type 2 Diabetes Mellitus: Addressing the Barriers to Albuminuria Testing.

机构信息

Endocrinology Associates Inc, Columbus, OH, USA.

Case Western Reserve University School of Medicine, Cleveland, OH, USA.

出版信息

J Prim Care Community Health. 2021 Jan-Dec;12:21501327211003683. doi: 10.1177/21501327211003683.

DOI:10.1177/21501327211003683
PMID:33749371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7983418/
Abstract

Chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) is associated with increased risk of end-stage renal disease (ESRD) and cardiovascular disease (CVD). Urine albumin-to-creatinine ratio (UACR) is a sensitive and early indicator of kidney damage, which should be used routinely to accurately assess CKD stage and monitor kidney health. However, this test currently is performed in only a minority of patients with T2D. Here, we review the importance of albuminuria testing and current barriers that hinder patient access to UACR testing and describe solutions to such testing in a community clinical setting.

摘要

2 型糖尿病(T2D)患者的慢性肾脏病(CKD)与终末期肾病(ESRD)和心血管疾病(CVD)的风险增加有关。尿白蛋白与肌酐比值(UACR)是肾脏损伤的敏感和早期指标,应常规用于准确评估 CKD 分期和监测肾脏健康。然而,目前只有少数 T2D 患者进行了这项检查。在这里,我们回顾了蛋白尿检测的重要性以及目前阻碍患者接受 UACR 检测的障碍,并描述了在社区临床环境中解决此类检测的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/724e/7983418/4a40d27341f0/10.1177_21501327211003683-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/724e/7983418/4a40d27341f0/10.1177_21501327211003683-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/724e/7983418/4a40d27341f0/10.1177_21501327211003683-fig1.jpg

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1
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2
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Diabetes Care. 2021 Jan;44(Suppl 1):S1-S2. doi: 10.2337/dc21-Sint.
3
CKD Awareness Among US Adults by Future Risk of Kidney Failure.未来发生肾衰竭风险对美国成年人慢性肾脏病知晓率的影响。
降低慢性肾病合并2型糖尿病患者心血管风险的治疗策略。
J Intern Med. 2025 May;297(5):460-478. doi: 10.1111/joim.20050. Epub 2024 Dec 31.
4
Portable Electrochemical System and Platform with Point-of-Care Determination of Urine Albumin-to-Creatinine Ratio to Evaluate Chronic Kidney Disease and Cardiorenal Syndrome.便携式电化学系统和平台,用于即时检测尿液白蛋白与肌酐比值,以评估慢性肾脏病和心肾综合征。
Biosensors (Basel). 2024 Sep 27;14(10):463. doi: 10.3390/bios14100463.
5
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Cureus. 2024 Sep 22;16(9):e69946. doi: 10.7759/cureus.69946. eCollection 2024 Sep.
6
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4
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6
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7
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9
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