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险些发生的严重孕产妇不良事件:孕产妇险些发生的严重不良事件及围产期结局的决定因素:一项来自印度三级医疗中心的前瞻性病例对照研究

Near miss: determinants of maternal near miss and perinatal outcomes: a prospective case control study from a tertiary care center of India.

作者信息

Agarwal Neha, Jain Vanita, Bagga Rashmi, Sikka Pooja, Chopra Seema, Jain Kajal

机构信息

Department of Obstetrics and Gynecology, Lok Nayak Jai Prakash Narayan Hospital, New Delhi, India.

Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

J Matern Fetal Neonatal Med. 2022 Dec;35(25):5909-5916. doi: 10.1080/14767058.2021.1902497. Epub 2021 Mar 21.

Abstract

BACKGROUND/PURPOSE: To study the causes of maternal near miss and compared maternal and perinatal outcome of maternal near miss cases with controls (women with potential life-threatening complication [PLTC]) and maternal death.

METHODS

Mothers ( = 100) who fulfilled the WHO criteria for maternal near miss (MNM) were identified and enrolled in the study. Two controls for each near miss case were taken. This included the women who had same PLTC but did not reach near miss within one week of enrollment. The comparison of maternal and fetal outcome was done between the two groups and with the maternal death (MD) group, who presented initially as near miss.

RESULTS

Obstetric hemorrhage was the most common potential life-threatening complication in MNM and MD group. On multiple logistic regression analysis, we found that the presence of organ dysfunction was the independent predictor of near miss and need of mechanical ventilation and coagulation dysfunction as an independent predictor of maternal death. A mother in the near miss group or death group had a higher chance of giving birth to a still-born child ( = < 0.001). Risk of neonatal death after NICU admission was numerically more among near miss and death group than controls, although statistically insignificant ( > .05).

CONCLUSION

Despite making tremendous progress in obstetric care facilities at a tertiary level, developing countries need to strengthen primary care infrastructure and referral system. To improve maternal care, there should be the provision of health education for all pregnant women and antenatal services should be improved.

摘要

背景/目的:研究孕产妇接近死亡的原因,并比较孕产妇接近死亡病例与对照组(有潜在危及生命并发症[PLTC]的妇女)及孕产妇死亡的孕产妇和围产儿结局。

方法

确定并纳入100名符合世界卫生组织孕产妇接近死亡(MNM)标准的母亲进行研究。为每个接近死亡病例选取两名对照。这包括患有相同PLTC但在入组后一周内未达到接近死亡状态的妇女。对两组之间以及与最初表现为接近死亡的孕产妇死亡(MD)组的孕产妇和胎儿结局进行比较。

结果

产科出血是MNM组和MD组最常见的潜在危及生命的并发症。多因素逻辑回归分析发现,器官功能障碍的存在是接近死亡的独立预测因素,机械通气需求和凝血功能障碍是孕产妇死亡的独立预测因素。接近死亡组或死亡组的母亲生出死产儿的几率更高(P = <0.001)。尽管统计学上无显著差异(P>0.05),但接近死亡组和死亡组新生儿入住新生儿重症监护病房(NICU)后的死亡风险在数值上高于对照组。

结论

尽管三级产科护理设施取得了巨大进展,但发展中国家仍需加强初级保健基础设施和转诊系统。为改善孕产妇护理,应为所有孕妇提供健康教育,并应改善产前服务。

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