Centre for Biotechnology, M. D. University, Rohtak, India.
Faculty of Pharmaceutical Sciences, PDM University, Bahadurgarh, India.
Mini Rev Med Chem. 2021;21(16):2337-2346. doi: 10.2174/1389557521666210322162913.
Fungi are recognized as key pathogens in immunocompromised patients. The invasive infection always remains a problem for clinicians due to high morbidity and mortality. The treatments of fungal infections are hampered by conventional drugs, which are associated with resistance. Drug resistance has become an important problem in a variety of infectious diseases. The rise in the incidence of fungal infections and drug resistance has intensified the need for alternative therapies that affect a new target. This new target must be a growth essential gene product like the stress pathway. It has been found that stress pathways can be a potential target in opportunistic fungal infection, which played an important role in the virulence of pathogens. It was helpful in protection from host defense, normal fungal growth, and antifungal drug resistance. The disruption of the pathway using alternative strategies (chemosensitization and photo-dynamics therapy) can be a novel approach in fighting fungal infections and for drug design.
真菌被认为是免疫功能低下患者的主要病原体。由于发病率和死亡率高，侵袭性感染一直是临床医生面临的问题。由于传统药物存在耐药性，真菌感染的治疗受到阻碍。耐药性已成为各种传染病的一个重要问题。真菌感染和耐药性的上升加剧了对影响新靶点的替代疗法的需求。这个新的靶点必须是一个像应激途径这样的生长必需基因产物。已经发现，应激途径可能是机会性真菌感染的一个潜在靶点，它在病原体的毒力中起着重要作用。它有助于宿主防御、正常真菌生长和抗真菌药物耐药性。使用替代策略（化学增敏和光动力学治疗）破坏该途径可能是对抗真菌感染和药物设计的一种新方法。
