Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang, 110819, P. R. China.
J Antibiot (Tokyo). 2018 Nov;71(12):978-991. doi: 10.1038/s41429-018-0100-9. Epub 2018 Sep 21.
In recent years, incidences of invasive fungal infections have greatly increased, especially in immunosuppressed patients, but most today's antifungal drugs are not completely effective due to the development of drug resistance, as well as potential toxicity and adverse effects. Consequently, it is imperative to search for novel antifungal agents to combat fungal infections. This review will discuss the advances in the traditional antifungal therapy, and present an overview of novel strategies for the treatment of fungal infections. The papers presented here highlight new targets that could be exploited for development of new antifungal agents.
近年来，侵袭性真菌感染的发病率大大增加，尤其是在免疫抑制患者中，但由于耐药性的发展以及潜在的毒性和不良反应，目前大多数抗真菌药物并不完全有效。因此，迫切需要寻找新型抗真菌药物来对抗真菌感染。本综述将讨论传统抗真菌治疗的进展，并概述治疗真菌感染的新策略。本文介绍的论文强调了可用于开发新型抗真菌药物的新靶标。
