血管活性肠肽对大鼠脑内多巴胺能系统的影响。
Effect of vasoactive intestinal peptide on dopaminergic system in the rat brain.
作者信息
Itoh S, Katsuura G, Takashima A
机构信息
Shionogi Research Laboratories, Osaka, Japan.
出版信息
Peptides. 1988 Mar-Apr;9(2):315-7. doi: 10.1016/0196-9781(88)90266-5.
PMID:3375138
Abstract
The present study analyzed the effect of vasoactive intestinal peptide (VIP) on the content of dopamine (DA) and its main metabolite, DOPAC, in the rat brain. Intracerebroventricular administration of VIP increased the DA and DOPAC content, causing a dose-dependent increase in the DOPAC/DA ratio in various regions of the brain. The results suggest that VIP facilitates the DA metabolism in the brain.
摘要
本研究分析了血管活性肠肽（VIP）对大鼠脑内多巴胺（DA）及其主要代谢产物3,4-二羟基苯乙酸（DOPAC）含量的影响。脑室内注射VIP可增加DA和DOPAC的含量，使脑内各区域的DOPAC/DA比值呈剂量依赖性升高。结果表明，VIP可促进脑内DA的代谢。
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