Mirmiran M, Kruisbrink J, Bos N P, Van der Werf D, Boer G J
Netherlands Institute for Brain Research, Amsterdam.
Brain Res. 1988 Aug 16;458(1):192-4. doi: 10.1016/0006-8993(88)90516-1.
Vasoactive intestinal polypeptide (VIP) has been shown to increase the amount of time spent in rapid-eye-movement (REM) sleep both in cats and in rats. In the present study we examined the effect of a newly available competitive VIP-antagonist ([4Cl-D-Phe6-Leu17]-VIP) on sleep-wake patterns in male rats during both the light and the dark phase of 24 h. Continuous intracerebroventricular application of this VIP-antagonist reduced by 44% the amount of time spent in REM sleep during the light period. It is concluded that VIP may play a role in the generation and maintenance of REM sleep.
血管活性肠肽（VIP）已被证明能增加猫和大鼠快速眼动（REM）睡眠的时长。在本研究中，我们检测了一种新的竞争性VIP拮抗剂（[4Cl-D-Phe6-Leu17]-VIP）对雄性大鼠在24小时光照期和黑暗期睡眠-觉醒模式的影响。持续脑室内注射这种VIP拮抗剂可使光照期REM睡眠时长减少44%。由此得出结论，VIP可能在REM睡眠的产生和维持中发挥作用。
