通过在大鼠脑室内应用血管活性肠肽拮抗剂减少光照下的快速眼动睡眠。

Decrease of rapid-eye-movement sleep in the light by intraventricular application of a VIP-antagonist in the rat.

作者信息

Mirmiran M, Kruisbrink J, Bos N P, Van der Werf D, Boer G J

机构信息

Netherlands Institute for Brain Research, Amsterdam.

出版信息

Brain Res. 1988 Aug 16;458(1):192-4. doi: 10.1016/0006-8993(88)90516-1.

DOI:10.1016/0006-8993(88)90516-1

PMID:3208098

Abstract

Vasoactive intestinal polypeptide (VIP) has been shown to increase the amount of time spent in rapid-eye-movement (REM) sleep both in cats and in rats. In the present study we examined the effect of a newly available competitive VIP-antagonist ([4Cl-D-Phe6-Leu17]-VIP) on sleep-wake patterns in male rats during both the light and the dark phase of 24 h. Continuous intracerebroventricular application of this VIP-antagonist reduced by 44% the amount of time spent in REM sleep during the light period. It is concluded that VIP may play a role in the generation and maintenance of REM sleep.

摘要

血管活性肠肽（VIP）已被证明能增加猫和大鼠快速眼动（REM）睡眠的时长。在本研究中，我们检测了一种新的竞争性VIP拮抗剂（[4Cl-D-Phe6-Leu17]-VIP）对雄性大鼠在24小时光照期和黑暗期睡眠-觉醒模式的影响。持续脑室内注射这种VIP拮抗剂可使光照期REM睡眠时长减少44%。由此得出结论，VIP可能在REM睡眠的产生和维持中发挥作用。