黄素辅酶稳态在人类神经肌肉病理中的改变。

Alteration of Flavin Cofactor Homeostasis in Human Neuromuscular Pathologies.

机构信息

Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari "A. Moro", Bari, Italy.

出版信息

Methods Mol Biol. 2021;2280:275-295. doi: 10.1007/978-1-0716-1286-6_18.

Abstract

The aim of this short review chapter is to provide a brief summary of the relevance of riboflavin (Rf or vitamin B2) and its derived cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) for human neuromuscular bioenergetics.Therefore, as a completion of this book we would like to summarize what kind of human pathologies could derive from genetic disturbances of Rf transport, flavin cofactor synthesis and delivery to nascent apoflavoproteins, as well as by alteration of vitamin recycling during protein turnover.

摘要

本章的目的是简要总结核黄素（Rf 或维生素 B2）及其衍生辅因子黄素单核苷酸（FMN）和黄素腺嘌呤二核苷酸（FAD）对人类神经肌肉生物能量学的重要性。因此，作为本书的补充，我们将总结一下由于 Rf 转运、黄素辅因子合成和向新生脱辅基蛋白的传递遗传障碍，以及蛋白质周转过程中维生素循环改变，可能会导致哪些人类疾病。