Elmehrath Ahmed O, Afifi Ahmed M, Abdel-Malek Raafat
Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Internal Medicine, Division of Digestive Diseases, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
J Obstet Gynaecol Res. 2021 May;47(5):1884-1891. doi: 10.1111/jog.14736. Epub 2021 Mar 9.
Research on non-cancer death causes in ovarian cancer (OC) patients remains limited. We aim to focus on and evaluate the non-cancer death causes after OC diagnosis.
We studied 82 590 OC patients diagnosed between 2000 and 2016, using the Surveillance, Epidemiology, and End Results (SEER) Program. Risks of death causes were calculated as standardized mortality ratios.
Of included patients, 48 125 (58.3%) died during the follow-up period. The highest number of deaths, 21 722 (45.1%), occurred within 1-5 years after OC diagnosis. On the other hand, 19 992 (41.5%) of deaths occurred within a year from ovary cancer diagnosis, 5255 (10.9%) occurred within 5-10 years, and 1156 (2.4%) deaths occurred after more than 10 years following OC diagnosis. Non-cancer death causes comprise a significant percentage of deaths in OC patients, increasing with time after diagnosis.
Cardiac diseases, cerebrovascular diseases, and COPD were among the most common non-cancer death causes after OC diagnosis. Other critical non-cancer death causes include septicemia and benign neoplasms. Mortality risk differences based on race and age were also highlighted. These findings provide critical insights into how OC survivors should be followed-up and counseled for relevant future health risks.
关于卵巢癌（OC）患者非癌症死亡原因的研究仍然有限。我们旨在关注并评估OC诊断后的非癌症死亡原因。
我们使用监测、流行病学和最终结果（SEER）计划研究了2000年至2016年间诊断出的82590例OC患者。死亡原因的风险以标准化死亡率计算。
在纳入的患者中，48125例（58.3%）在随访期间死亡。死亡人数最多的是21722例（45.1%），发生在OC诊断后的1至5年内。另一方面，19992例（41.5%）死亡发生在卵巢癌诊断后的一年内，5255例（10.9%）发生在5至10年内，1156例（2.4%）死亡发生在OC诊断后的10年以上。非癌症死亡原因在OC患者的死亡中占很大比例，并随着诊断后的时间增加。
心脏病、脑血管疾病和慢性阻塞性肺疾病是OC诊断后最常见的非癌症死亡原因。其他关键的非癌症死亡原因包括败血症和良性肿瘤。还强调了基于种族和年龄的死亡风险差异。这些发现为如何对OC幸存者进行随访以及就相关未来健康风险提供咨询提供了关键见解。
