Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Cancer Med. 2023 May;12(9):10917-10930. doi: 10.1002/cam4.5804. Epub 2023 Mar 16.
Increasing attention has been paid to the survival of endometrial cancer (EC) patients, but the non-cancer causes of death from EC are rarely reported. This study primarily aimed to investigate the non-cancer causes of death in patients with EC.
The study collected relevant data, including age, tumour stage and treatment mode, on patients diagnosed with endometrial malignancies from 2000 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) Programme. We analysed the standardised mortality ratio (SMR) to determine the cause of death.
The study included 135,831 patients with EC. During the follow-up, 46,604 (34.3%) patients died, of whom 42.9%, 15.6% and 41.5% died of EC, other cancers and non-cancer causes, respectively. As the diagnosis time increased, the number of EC-associated mortalities gradually decreased. The most common non-cancer causes of death were heart disease, cerebrovascular disease and diabetes. Regarding the general population of the United States, patients with EC died of heart disease (SMR: 1.06; 95% confidence interval [CI]: 1.03-1.09), diabetes (SMR: 1.56; 95% CI: 1.47-1.65) and septicaemia (SMR: 1.40; 95% CI: 1.28-1.52), which were statistically significant.
For patients with EC, the number of deaths from non-cancer causes (mainly heart disease, cerebrovascular disease and diabetes mellitus) is equivalent to that of EC. In addition, compared with the general population, EC survivors have a higher risk of death from sepsis and diabetes. These discoveries support how survivors can avoid future-related health risks. By doing this, clinicians can improve the quality of life and chances of the survival of patients with EC.
人们越来越关注子宫内膜癌（EC）患者的生存情况，但 EC 患者的非癌症死因却鲜有报道。本研究主要旨在探讨 EC 患者的非癌症死因。
本研究收集了 2000 年至 2015 年期间在监测、流行病学和最终结果（SEER）计划中诊断为子宫内膜恶性肿瘤的患者相关数据，包括年龄、肿瘤分期和治疗模式。我们分析了标准化死亡率（SMR）以确定死因。
本研究纳入了 135831 例 EC 患者。在随访期间，46604（34.3%）例患者死亡，其中 42.9%、15.6%和 41.5%分别死于 EC、其他癌症和非癌症原因。随着诊断时间的延长，EC 相关死亡人数逐渐减少。最常见的非癌症死因是心脏病、脑血管病和糖尿病。与美国一般人群相比，EC 患者死于心脏病（SMR：1.06；95%置信区间 [CI]：1.03-1.09）、糖尿病（SMR：1.56；95% CI：1.47-1.65）和败血症（SMR：1.40；95% CI：1.28-1.52），差异有统计学意义。
对于 EC 患者，非癌症死因（主要是心脏病、脑血管病和糖尿病）的死亡人数与 EC 相当。此外，与一般人群相比，EC 幸存者死于败血症和糖尿病的风险更高。这些发现支持了幸存者如何避免未来相关的健康风险。通过这样做，临床医生可以提高 EC 患者的生活质量和生存机会。
