The Second Clinical Medical College of Lanzhou University, 82 Cuiying Men, Lanzhou 730030, PR China; Orthopedics Key Laboratory of Gansu Province, Lanzhou 730000, PR China.
Orthopedics Key Laboratory of Gansu Province, Lanzhou 730000, PR China; The First Clinical Medical College of Lanzhou University, 1 Donggang Road, Lanzhou 730000, PR China.
Biomed Pharmacother. 2021 Jun;138:111472. doi: 10.1016/j.biopha.2021.111472. Epub 2021 Mar 19.
CDGSH iron-sulfur domain 2 (Cisd2) is an evolutionarily conserved protein that plays an important regulatory role in aging-related diseases and cancers. Since its discovery, Cisd2 has been identified as a regulatory factor for the aging of the human body and the regulation of mammalian lifespan. Cisd2 is also an oncoprotein that regulates the occurrence and development of cancer. Cisd2 mediates the occurrence of diseases related to human aging and the proliferation, differentiation, metastasis, and invasion of various cancer cells through various mechanisms. Multiple studies have shown that Cisd2 expression is related to the clinical characteristics of aging-related diseases and patients with cancer, and its expression profile is a novel diagnostic and prognostic biomarker for a variety of human diseases. Modulating the expression or function of Cisd2 may be a potential treatment strategy for different diseases. In this review, we summarize the role of Cisd2 in human aging-related diseases and various cancers, as well as the biological functions, underlying mechanisms, and potential clinical significance.
CDGSH 铁硫结构域 2（Cisd2）是一种进化上保守的蛋白质，在与衰老相关的疾病和癌症中发挥着重要的调节作用。自发现以来，Cisd2 被确定为调节人体衰老和哺乳动物寿命的调节因子。Cisd2 也是一种癌蛋白，调节癌症的发生和发展。Cisd2 通过多种机制介导与人类衰老相关的疾病的发生以及各种癌细胞的增殖、分化、转移和侵袭。多项研究表明，Cisd2 的表达与衰老相关疾病患者和癌症患者的临床特征有关，其表达谱是多种人类疾病的新型诊断和预后生物标志物。调节 Cisd2 的表达或功能可能是治疗不同疾病的一种潜在策略。在这篇综述中，我们总结了 Cisd2 在人类衰老相关疾病和各种癌症中的作用，以及其生物学功能、潜在机制和潜在的临床意义。
