Deparment of Surgical Oncology, Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, China.
Department of Oncology Radiotherapy, Lu'an Hospital of Traditional Chinese Medicine, Lu'an, China.
Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033821990055. doi: 10.1177/1533033821990055.
Some evidence supports that the significance of inflammation is linked to a variety of tumors, including thyroid carcinoma. This work measured the preoperative serum inflammatory factors in thyroid tumors to explore their diagnostic values.
Altogether 487 thyroid tumor patients were recruited, their neutrophil (NE), white blood cell (WBC), monocyte (MO), lymphocyte (LY), platelet (PLT) counts, together with monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), C-reactive protein (CRP), interleukin (IL)-1β, IL-2, IL-27, and tumor necrosis factor-α (TNF-α) levels were compared with controls. Afterward, the receiver operating characteristics (ROC) curve was plotted to further evaluate the values of these inflammatory markers in diagnosis. In addition, multivariable regression analysis was conducted to analyze all these inflammatory factors.
Serum PLR, NLR, CRP, and IL-27 levels in thyroid adenoma (TA) and differentiated thyroid carcinoma (DTC) patients were higher than those in controls. Only the areas under the curve (AUC) for CRP and IL-27 were significant in the context of DTC. Besides, the AUC for IL-27 was significant between papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) groups, while that for NLR+PLR was also significant between PTC and healthy control groups. According to multivariable logistic regression analysis, IL-27 and CRP were associated with DTC.
Inflammation plays an important role in TA and DTC progression. Preoperative IL-27 and CRP levels help to differentially diagnose DTC. Moreover, IL-27 assists in distinguishing FTC from PTC, and NLR+PLR is important for the differential diagnosis of PTC.
有证据表明，炎症的意义与多种肿瘤有关，包括甲状腺癌。本研究测量了甲状腺肿瘤患者术前血清中的炎症因子，以探讨其诊断价值。
共招募了 487 例甲状腺肿瘤患者，比较其中性粒细胞（NE）、白细胞（WBC）、单核细胞（MO）、淋巴细胞（LY）、血小板（PLT）计数，以及单核细胞/淋巴细胞比值（MLR）、中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、C 反应蛋白（CRP）、白细胞介素（IL）-1β、IL-2、IL-27 和肿瘤坏死因子-α（TNF-α）水平与对照组相比。随后，通过绘制受试者工作特征（ROC）曲线进一步评估这些炎症标志物的诊断价值。此外，还进行了多变量回归分析，以分析所有这些炎症因子。
甲状腺腺瘤（TA）和分化型甲状腺癌（DTC）患者的血清 PLR、NLR、CRP 和 IL-27 水平高于对照组。仅 CRP 和 IL-27 的曲线下面积（AUC）在 DTC 中有统计学意义。此外，IL-27 的 AUC 在甲状腺乳头状癌（PTC）和滤泡状甲状腺癌（FTC）组之间有显著差异，而 NLR+PLR 在 PTC 和健康对照组之间也有显著差异。根据多变量逻辑回归分析，IL-27 和 CRP 与 DTC 相关。
炎症在 TA 和 DTC 的进展中起重要作用。术前 IL-27 和 CRP 水平有助于鉴别诊断 DTC。此外，IL-27 有助于鉴别 FTC 与 PTC，NLR+PLR 对 PTC 的鉴别诊断具有重要意义。
