Ari Aziz, Gunver Feray
1 Department of General Surgery, Istanbul Training and Research Hospital, Istanbul, Turkey.
2 Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.
J Int Med Res. 2019 May;47(5):2077-2083. doi: 10.1177/0300060519838392. Epub 2019 Mar 26.
The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have recently been introduced as prognostic markers of thyroid cancer and strong inflammatory markers. The study was performed to investigate the association of the PLR and NLR with thyroid inflammation and papillary cancer.
Patients with thyroiditis and patients with papillary carcinomas were compared with sex-, age-, and body mass index-matched healthy controls. The NLR and PLR were calculated and compared among the three groups.
The NLR was significantly higher in patients with thyroiditis and non-significantly higher in patients with papillary cancer than in healthy controls. The PLR was significantly higher in both patients with thyroiditis and papillary cancer than in healthy controls. Like the NLR, the PLR was not different between patients with thyroiditis and papillary cancer. The NLR was significantly and positively associated with the PLR and white blood cell count.
The PLR and NLR showed similar results in both thyroid inflammation and cancer. It seems difficult to obtain clear results in separating cancer from inflammatory events using these parameters. We suggest using them as supportive parameters of thyroid papillary cancer or inflammation.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）最近被引入作为甲状腺癌的预后标志物及强炎症标志物。本研究旨在探讨PLR和NLR与甲状腺炎症及乳头状癌之间的关联。
将甲状腺炎患者和乳头状癌患者与性别、年龄和体重指数相匹配的健康对照进行比较。计算并比较三组的NLR和PLR。
甲状腺炎患者的NLR显著高于健康对照，乳头状癌患者的NLR略高于健康对照但无显著差异。甲状腺炎患者和乳头状癌患者的PLR均显著高于健康对照。与NLR一样，甲状腺炎患者和乳头状癌患者之间的PLR无差异。NLR与PLR及白细胞计数显著正相关。
PLR和NLR在甲状腺炎症和癌症中显示出相似的结果。使用这些参数似乎难以从炎症事件中明确区分出癌症。我们建议将它们用作甲状腺乳头状癌或炎症的辅助参数。
