Metting P J, Duggan J M
Department of Physiology, Medical College of Ohio, Toledo 43699.
Proc Soc Exp Biol Med. 1988 Jun;188(2):212-8. doi: 10.3181/00379727-188-42730.
The purpose of these studies was to determine whether the accumulation of norepinephrine by the pulmonary circulation is altered in the Dahl model of genetic hypertension. Pulmonary norepinephrine accumulation was evaluated by performing a compartmental analysis of the efflux of L-[3H]norepinephrine from perfused lungs after inhibition of the norepinephrine-metabolizing enzymes. The lungs were isolated from Dahl salt-hypertension-susceptible (S) and salt-hypertension-resistant (R) rats that had been on a high sodium diet for 3 weeks. In both S and R rats, norepinephrine was accumulated into a single compartment with an efflux half-time of approximately 23 min, in addition to its distribution in the extracellular space. The size of the extracellular space was significantly increased in the S rats, but there was no difference in the size of the compartment of L-[3H]norepinephrine efflux between S (6.4 +/- 1.2 ml/g) and R (3.7 +/- 0.7 ml/g) rats. These data indicate that impaired accumulation and efflux of norepinephrine by the lungs does not contribute to the pathogenesis of hypertension in Dahl S rats.
这些研究的目的是确定在遗传性高血压的 Dahl 模型中，肺循环中去甲肾上腺素的蓄积是否发生改变。通过在抑制去甲肾上腺素代谢酶后，对灌注肺中 L-[3H]去甲肾上腺素的流出进行房室分析，来评估肺去甲肾上腺素的蓄积情况。从食用高钠饮食 3 周的 Dahl 盐敏感性高血压（S）大鼠和盐抵抗性高血压（R）大鼠中分离出肺。在 S 大鼠和 R 大鼠中，除了去甲肾上腺素在细胞外空间的分布外，它还蓄积到一个单一房室中，流出半衰期约为 23 分钟。S 大鼠的细胞外空间大小显著增加，但 S 大鼠（6.4±1.2 ml/g）和 R 大鼠（3.7±0.7 ml/g）之间 L-[3H]去甲肾上腺素流出房室的大小没有差异。这些数据表明，肺对去甲肾上腺素的蓄积和流出受损并不促成 Dahl S 大鼠高血压的发病机制。
